Chronic Obstructive Pulmonary Disease (COPD) Clinical Trial
Official title:
Effects of Acute Intravenous Magnesium Loading on Pulmonary Function Parameters and Maximal Exercise Capacity of Patients With Chronic Obstructive Pulmonary Disease in Stable Clinical Conditions.
Dietary magnesium (Mg) intake has been shown to be independently related to lung function, airway reactivity, and respiratory symptoms in the general population. Inhaled Mg and IV Mg administration have been shown to promote bronchodilation and to improve lung function in asthmatic patients. Some studies have suggested that COPD patients exhibit decreased body levels of Mg. The purpose of the present study was to investigate the effects of acute IV Mg loading on parameters of respiratory function and maximal exercise capacity of stable COPD patients.The study hypothesis is that Mg administration will be associated to improvements on airflow and vasodilation leading to improvements of pulmonary function and exercise performance.
Patients are required to have a diagnosis of COPD according to the Global Initiative for
Chronic Obstructive Lung Disease criteria.
This is a randomized, double-blind, placebo-controlled, cross-over study. Twenty five
patients are going to be included. They are going to come to the laboratory to receive IV
placebo or IV Mg sulfate at two distinct occasions about 48 hours apart. Half of the
patients are going to receive Mg first and Placebo at the second day, while the other half
are going to receive the treatments in an inverse order. Tests are going to be performed
before and about 40 minutes after the IV infusions. Tests to be performed are: spirometry,
arterial blood gases, Mg plasma level measurements, and a maximal exercise test protocol in
cycloergometer.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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