Chronic Obstructive Pulmonary Disease (COPD) Clinical Trial
Official title:
The Effects of Bronchodilators on Exertional Dyspnea and Exercise Performance in Mild Chronic Obstructive Pulmonary Disease (COPD) Patients and Healthy Elderly Subjects.
In people with mild COPD, the ability to exhale air from the lungs is partly limited because
of narrowing and collapse of the airways. This results in the trapping of air within the
lungs and over-distention of the lungs and chest (lung hyperinflation).
Breathing at high lung volumes (hyperinflation) is an important cause of breathing
discomfort (dyspnea) in people with COPD. Bronchodilators help to relax muscles in the
airways or breathing tubes. Bronchodilators are often prescribed if a cough occurs with
airway narrowing as this medication can reduce coughing, wheezing and shortness of breath.
Bronchodilators can be taken orally, through injection or through inhalation and begin to
act almost immediately but with the effect only lasting 4-6 hours. The main purpose of this
study is to examine the effects of inhaled bronchodilators on breathing discomfort and
exercise endurance in patients with mild COPD.
In people with mild COPD, the ability to exhale air from the lungs is partly limited because
of narrowing and collapse of the airways. This results in the trapping of air within the
lungs and over-distention of the lungs and chest - this is known as lung hyperinflation. We
believe that breathing at high lung volumes (hyperinflation) is an important cause of
breathing discomfort (dyspnea) in people with COPD. Bronchodilators help to relax muscles in
the airways or breathing tubes. Bronchodilators are often prescribed if a cough occurs with
airway narrowing; this medication can reduce coughing, wheezing and shortness of breath.
Bronchodilators can be taken orally, through injection or through inhalation and begin to
act almost immediately but with the effect only lasting 4-6 hours. The main purpose of this
study is to examine the effects of inhaled bronchodilators on breathing discomfort and
exercise endurance in patients with mild COPD.
Each subject will attend 4 visits to the laboratory. Visit 1 (screening visit) will involve
a record of medical history, medications used, anthropometrics measurements, questionnaires,
breathing tests, an incremental cycle exercise test and a constant-workload cycle exercise
test. Visit 2 will involve breathing tests and a constant-workload cycle exercise test.
Visits 3 and 4 will involve breathing tests and a constant-workload cycle exercise test
after subjects have been randomized to either placebo or Atrovent. These visits will be done
on separate days and subjects will receive the two above treatments in random order.
;
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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