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NCT00159237 Clinical Trial

GR Defect in Peripheral Blood Mononuclear Cells in COPD

Chronic Obstructive Pulmonary Disease Clinical Trial

Official title:
GR Defect in Peripheral Blood Mononuclear Cells in COPD

Clinical Trial Details — Status: Withdrawn

Administrative data
NCT number NCT00159237
Other study ID # D5899N00007
Secondary ID
Status Withdrawn
Phase
First received
Last updated
Start date February 2005
Est. completion date December 2008

Study information
Verified date July 2019
Source Imperial College London
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

T.to investigate a possible mechanism of the glucocorticosteroid receptors (GR) defect in patients with severe COPD by studying the effect of dexamethasone (Dex) on GR- binding, interleukin production (IL-6/IL-8) and MKP-1 expression in peripheral blood mononuclear cells blood (PBMC)

Recruitment information / eligibility
Status Withdrawn
Enrollment 0
Est. completion date December 2008
Est. primary completion date December 2008
Accepts healthy volunteers No
Gender All
Age group 35 Years to 85 Years
Eligibility Inclusion Criteria:

- Patients with severe (stage III, Gold) to very severe (stage IV, GOLD) COPD or subjects who are healthy smokers or subjects who are non-smokers

- Written informed consent

Exclusion Criteria:

- Current upper respiratory tract infections

- Any significant disease or disorder (e.g. cardiovascular, pulmonary (other than asthma), gastrointestinal, liver, renal, neurological, musculoskeletal, endocrine, metabolic, malignant, psychiatric, major physical impairment) which, in the opinion of the investigator, may either put the subject at risk because of participation in the study, or may influence the results of the study, or the subjects ability to participate in the study

- Subjects not considered capable, as judged by the investigator, of following instructions of the study, e.g. because of a history of alcohol or drug abuse or any other reason

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• blood test

Locations
Country Name City State
United Kingdom Section of Airway Disease, Asthma Lab, Imperial College London, Royal Brompton Hospital London

Sponsors (2)
Lead Sponsor Collaborator
Imperial College London AstraZeneca

Country where clinical trial is conducted

United Kingdom, 

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