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Right Ventricular Diastolic Dysfunction — RVDD  

COPD Clinical Trial

Official title:
Interaction Between Right Heart Dysfunction and Emphysema: Impact of Endoscopic Lung Volume Reduction (RVDD)

Clinical Trial Summary

Heart-lung interactions remain misunderstood whereas pulmonary and cardiac pathologies are very commonly associated. Emphysema by increasing intrathoracic pressure appears to affect cardiac function. Interestingly, previous studies have shown a link between the telediastolic volume of the right ventricle (measured by RMI) and the intensity of emphysema. Our hypothesis is that the emphysema by increasing intrathoracic pressure leads to or accentuates right cardiac diastolic dysfunction by decreasing compliance and cardiac preload. To verify this hypothesis the investigators will perform KT loop procedures in order to acquire intracardiac pressure/volume curves before and after lung volume reduction. The pressure/volume curves allow the analysis of systolic and diastolic function, cardiac contractility and loading conditions.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04467242
Study type Observational
Source University Hospital, Montpellier
Contact Arnaud Bourdin, MD PhD
Phone 467336091
Email a-bourdin@chu-montpellier.fr
Status Recruiting
Phase
Start date July 20, 2020
Completion date June 1, 2022
View Details
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