Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Assessment of Reactance Parameters Measured by the Forced Oscillation Technique for the Bronchodilator Response in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
The aims of this study is :
- to assess the bronchodilator (DUOVENT HFA) response of parameters measured by the forced
oscillations (FOT) and in particular the reactance parameters related to the presence of
a limitation of expiratory flows
- to compare the response of the reactance parameters to bronchodilators with the
conventional spirometric parameters (FEV1) and inspiratory capacity (IC), and according
to the severity of the disease
- to assess and compare the relationship between the response to bronchodilators in terms
of IC on the one hand and on the other hand in terms of FEV1, reactance parameters
(measured by FOT), resistance parameters (measured by plethysmography and FOT)
- Assess and compare the relationship between dyspnea intensity assessed by various scales
and conventional respiratory function parameters (spirometry, plethysmography, diffusion
indices) and parameters measured by FOT
Different techniques will be used during this study :
First, the FOT. The measurements will be performed using a Tremoflo-type (Thorasys Thoracic
Medical System Inc.) device that generates an oscillating pressure waveform and measures
impedance of the respiratory system and its components (resistance and reactance) as a
function of frequency, as well as the respiratory system resonant frequency. Measurements
will be performed during tidal breathing, the subjects breathing through the pneumotachograph
of the system, with nose occluded, the cheeks supported by the hands (of the subjects or of
an operator) to reduce the influence of the compliant upper airways. Three measurements of
minimum 20 seconds duration will be recorded in the sitting position.
Second, the spirometry. The measurements will be carried out using a Medisoft Exp'air type of
equipment. The parameters will be successively measured in the sitting position :
- The inspiratory capacity (IC) will be measured by maximal inspiratory maneuver starting
from the functional residual capacity
- The thoracic gas volume (TGV), total lung capacity (TLC), as well as the airway
resistance will be measured by plethysmography
- The diffusion indices (CO transfer factor (DL,CO) and CO transfer coefficient (KCO))
will be measured in apnea
- A spirometry will then be carried out. Three maneuvers with acceptability and
reproducibility criteria will be performed
All these measurements will be carried out before the administration of the bronchodilator
and 30 minutes after the administration of the bronchodilator (4 puffs of DUOVENT HFA, using
an inhalation chamber).
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