Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Effectiveness of High Flow Nasal Nannula on Exercise Endurance Among Patients During Pulmonary Rehabilitation
The primary purpose of this study is to compare and assess the immediate and long-term
effects on pulmonary rehabilitation training with the usage of HFNC or conventional oxygen
therapy device.
The hypotheses was, with high flow nasal cannula usage while exercising, the physiological
outcome measurements would be better than conventional oxygen therapy device. Also, the usage
of HFNC can immediately increase patient's exercising endurance and decrease dyspnea caused
by exercising.
Pulmonary Rehabilitation is one of the most recommended methods to improve the muscle
function of COPD patients. By exercise training, even patients with severe COPD can increase
muscle strength, improve skeletal muscle function and enhance exercise endurance. Due to
improvements in exercise endurance, when exercising at a higher intensity, ventilation
support and dynamic hyperinflation would slightly decrease which leads to less dyspnea during
exercise. Continuously exercising can also increase the motivation to exercise, reduce mood
irritability and psychological burden caused by symptoms. By exercising, patient's health
status can be both improved physically and mentally.
High Flow Nasal Cannula (HFNC) is a non-invasive ventilatory device that provides stable
oxygen concentration, temperature (37℃) and humidity (Relative Humidity: 100%). Humidity
provided by the HFNC reduces irritation caused by the high flow, which leads to the increase
of user's tolerance with the device. With the half-closed system formed by a nasal prong,
when the high flow enters the upper airway, continue positive airway pressure would be
formed.
Subjects enrolled into this study are required to join a 6-week pulmonary rehabilitation
program. Before starting the program, subjects were randomly assigned to high flow nasal
cannula group and conventional oxygen therapy group. When exercising, the nasal cannula group
would receive an oxygen flow of 3 - 5L to maintain SpO2>90% and the HFNC group with high flow
setting of 45-50Lpm along with oxygen flow of 3-5L also to maintain SpO2>90%. When joining
the pulmonary rehabilitation program, patients are required to exercise for approximately 45
minutes per session. When exercising, changes in the degree of dyspnea, quadriceps blood flow
and hemodynamics are assessed. After 6-week of the exercise training, all the parameters will
again be assessed and compared to the primary data that was collected from the beginning of
the program.
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