Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Dietary Nitrate for COPD: a 14d, Randomized, Placebo-controlled, Crossover Trial
Acute consumption of dietary nitrate (as beetroot juice) has been shown to increase exercise and decrease systemic blood pressure in multiple populations, including COPD. The chronic effect of dietary nitrate in obstructive sleep apnea syndrome (OSAS) has not been reported.
Acute consumption of dietary nitrate (as beetroot juice) has been shown to increase exercise
and decrease systemic blood pressure in multiple populations, including COPD. The chronic
effect of dietary nitrate in OSAS has not been reported.
The investigators hypothesize that chronic nitrate consumption might increase exercise
tolerance, and exhaled NO but decrease blood pressure and have little impact on quality of
life and pulmonary function.
This study is a randomized, double-blind placebo-controlled, crossover trial. At baseline,
mid-point and endpoint exercise tolerance, pulmonary function, quality of life and
ambulatory blood pressure will be assessed in conjunction with demographics and blood draw.
After baseline measures, each subject will be randomized to consume nitrate rich beetroot
juice for 14 consecutive nights when assessments will be repeated followed by 14 nights of
placebo and endpoint assessments or the converse.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Supportive Care
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