Chronic Obstructive Pulmonary Disease (COPD) Clinical Trial
Official title:
A Phase III Double-blind, Randomised, Placebo Controlled Trial of Long Term Therapy on Exacerbation Rate in Patients With Stable COPD Using Doxycycline
This study investigates if long term use of the antibiotic doxycycline can reduce exacerbations in COPD patients. Half of the patients will receive doxycycline which the other half will receive a placebo.
Chronic Obstructive Pulmonary Disease (COPD) is a common disease which can place a
considerable burden on people who suffer from it. COPD exacerbations (periods when symptoms
flare up) are a major cause of hospital admission in the UK. Bacterial infections play an
important role in the development of COPD and so one possible treatment for COPD is with
antibiotics. However, there is little information available about the use of long term
antibiotics in the treatment of this disease.
Therefore, the purpose of this study is to investigate if long term use of the antibiotic
Doxycycline can reduce exacerbations and improve the outlook for these patients.
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