Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Evaluating Forced Oscillation Technique (FOT) in Abolishing Flow Limitation in Patients With Stable Chronic Pulmonary Disease (COPD)
To validate the capability of the Respironics Synchrony ventilator to properly detect Expiratory Flow Limitation (EFL) as compared to the gold standard method of detecting EFL via the Mead and Wittenberger technique.
Positive end expiratory pressure (PEEP) is used in COPD patients to counteract the intrinsic
PEEP (PEEPi), which represents the end expiratory recoil pressure of the total respiratory
system due to the presence of dynamic hyperinflation (DH).
DH commonly occurs in COPD, where the presence of expiratory flow-limitation (EFL) requires
the patient to breath at higher lung volumes to produce the necessary after appropriate leak
correction, showed a sensitivity and specificity in detecting EFL expiratory flow. To be
effective, the PEEP level applied to the patient should be equal to PEEPi.
The continuous monitoring of EFL could be a useful tool to select the minimum PEEP level
required to abolish it.
EFL can be detected using the forced oscillation technique (FOT) by an index which
quantifies, for each breath, the within-breath variations of respiratory reactance (delta
Xrs) at 5Hz.
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