Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Measurement of Biomarkers in the Exhaled Breath Condensate in Patients With Acute Exacerbations of Chronic Obstructive Pulmonary Disease
This study aimed to assess airway inflammation in patients during the course of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) by serial analyses of their exhaled breath condensates (EBC).
Subject recruitment
Patients who had been admitted to the Prince of Wales Hospital with AECOPD were recruited
for this study. Subjects with pneumonic changes on the chest radiographs were excluded. Age
and sex-matched COPD subjects at stable state (without AECOPD for at least 10 weeks) and
healthy, non-smoking subjects were recruited as controls.
Collection of exhaled breath condensate (EBC) EBC was collected using the EcoScreen (VIASYS
Healthcare, Conshohochen, PA, USA) according to the manufacturer's instructions. EBC was
stored in 250 microL aliquots immediately at -70oC until analysis. EBC was collected on Day
5, 14, 30 and 60 after hospitalization for subjects with AECOPD. For the stable COPD
patients and normal controls, EBC collection was performed once.
Measurement of TNF alpha, LTB4 and IL-8 The concentrations of TNF alpha, LTB4, and IL-8 in
EBC were measured in one batch by high-sensitivity sandwich enzyme immunoassays (TNF alpha
and IL-8 from BioSource International, Camarillo, CA, USA; LTB4 from Cayman Chemical
Company, Ann Arbor, MI, USA) according to the manufacturers' instructions. Intra-subject
repeatability of TNF alpha, LTB4 and IL-8 was assessed by collection of EBC in stable COPD
subjects. EBC was collected as described above at the same time (09:00 to 10:00) on 2
consecutive days.
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Observational Model: Case Control, Time Perspective: Prospective
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