Congestive Heart Failure Clinical Trial
— HENCHFOfficial title:
Hemodynamic Effects of Nesiritide on Congestive Heart Failure Patients Receiving Mechanical Ventilation: A Prospective Observational Study
NCT number | NCT04455477 |
Other study ID # | B2020-056R |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | May 14, 2020 |
Est. completion date | December 31, 2021 |
The congestive heart failure is a common disease among patients who receive cardiac surgery and may lead to prolonged ventilation support. Nesiritide was a potential therapy for congestive heart failure. This study aimed to compare the Nesiritide induced hemodynamical status changes among congestive heart failure patients with invasive ventilation support.
Status | Recruiting |
Enrollment | 30 |
Est. completion date | December 31, 2021 |
Est. primary completion date | December 31, 2021 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Age=18 years; - Congestive Heart Failure; - With mechanical ventilation; - With hemodynamic monitoring devices; - The physicians made the decision of using Nesiritide. Exclusion Criteria: - Unstable hemodynamic status; - Severe renal dysfunction. |
Country | Name | City | State |
---|---|---|---|
China | Zhongshan Hospital | Xuhui | Shanghai |
Lead Sponsor | Collaborator |
---|---|
Shanghai Zhongshan Hospital |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Changes of cardiac output | Changes of cardiac output measured by hemodynamical monitoring tools | Before and 30-min after using a standard dose of Nesiritide | |
Primary | Changes of systemic filling pressure | Changes of the intercept of regression line of paired VR-RAP points at different PEEP levels. | Before and 30-min after using a standard dose of Nesiritide | |
Secondary | Changes of cardiac function curve | Using body position changes (±15°) to simulate the change of preload, and therefore depicte the Starling curve | Before and 30-min after using a standard dose of Nesiritide | |
Secondary | Changes of venous return curve | Changes of venous return curve depicted by different PEEP setting | Before and 30-min after using a standard dose of Nesiritide |
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