Congestive Heart Failure Clinical Trial
Official title:
Effects of Acute L-NMMA Treatment on Renal Hemodynamics, Sodium and Water Excretion and Plasma Levels of Vasoactive Hormones in Patients With Congestive Heart Failure and Healthy Controls
The study tests the hypothesis that nitric oxide availability is changed in congestive heart failure with regard to the regulation of renal hemodynamics, renal sodium excretion and release of vasoactive hormones. The study tests these hypotheses by comparing the effects of systemic nitric oxide inhibition with L-NMMA in congestive heart failure patients with healthy subjects on renal hemodynamics, blood pressure and plasma levels of vasoactive hormones.
The purpose of the study is to investigate the effects of systemic treatment with
Ng-monomethyl-l-arginine in congestive heart failure and healthy controls on:
- glomerular filtration rate and renal plasma flow
- blood pressure and heart rate
- plasma levels of vasoactive hormones
- lithium clearance
The study is randomized and placebo controlled
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind
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