Clinical Trials Logo
  1. Home
  2. Complex Regional Pain Syndrome
  3. NCT06393101

The Effects and Mechanisms of a High CBD Cannabis Extract (BRC-002) for the Treatment of Pain and Health in Complex Regional Pain Syndrome

Complex Regional Pain Syndrome Clinical Trial

Official title:
A Randomized, Double-blind, Placebo-controlled Study to Investigate the Effects and Mechanisms of a High CBD Cannabis Extract (BRC-002) for the Treatment of Pain and Health in Complex Regional Pain Syndrome

Clinical Trial Summary

The aim of this trial is to determine the potential effects and mechanisms of cannabinoid-induced pain relief in complex regional pain syndrome (CRPS). Multiple psychophysical approaches will be conducted in conjunction with psychological and inflammatory marker testing to determine if and how cannabinoids produce stabilized improvement in CRPS-related pain and comorbidities. The trial consisted of a pre-treatment screening period, six-week treatment period and a two-week follow-up.

Clinical Trial Description

Complex Regional Pain Syndrome (CRPS) is a debilitating and perplexing chronic pain condition that produces incalculable suffering to millions of individuals worldwide. The United States alone has a reported 200,000 individuals living with CRPS. The enigmatic nature of CRPS has left it difficult to treat. CRPS is characterized by a constellation of pain, sensory, autonomic, and motor symptoms that is difficult to pinpoint the source of injury/inflammation. Although unclear, a common cause of CRPS are radial fractures that demonstrate aberrant processing 4-6 weeks after injury. The aim of this trial is to determine the potential effects and mechanisms of cannabinoid-induced pain relief in complex regional pain syndrome (CRPS). Multiple psychophysical approaches will be conducted in conjunction with psychological and inflammatory marker testing to determine if and how cannabinoids produce stabilized improvement in CRPS-related pain and comorbidities. The trial consisted of a pre-treatment screening period, six-week treatment period and a two-week follow-up. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06393101
Study type Interventional
Source University of California, San Diego
Contact Fadel Zeidan, PhD
Phone 858-246-8341
Email fzeidan@health.ucsd.edu
Status Recruiting
Phase Early Phase 1
Start date June 1, 2024
Completion date June 1, 2029
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT02753335 - A Comparison of Two Treatments for CRPS and Changes in Resting-State Connectivity of Cerebral Networks. N/A
Recruiting NCT01134289 - Analysis of Photoplethysmographic Signal in Lumbar Sympathetic Block Phase 3
Completed NCT00579085 - Double Blind Placebo Controlled Study of Outpatient Intravenous Ketamine for the Treatment of CRPS Phase 2
Completed NCT02837822 - Effects of Spinal Cord Stimulation on Sensory Perceptions of Chronic Pain Patients N/A
Completed NCT02070367 - Somatosensory Assessment and Rehabilitation of Allodynia (SARA) N/A
Completed NCT00462566 - The Efficacy of Motor Cortex Stimulation for Pain Control N/A
Active, not recruiting NCT03228160 - Light Irradiation and Outcome for Neuropathic Pain N/A
Terminated NCT02094352 - Randomized Controlled Trial of Ketamine Infusion With Continuous Epidural Infusion for Treatment of Complex Regional Pain Syndrome Phase 2
Recruiting NCT02502162 - Low-Dose Naltrexone for the Treatment of Complex Regional Pain Syndrome N/A
Completed NCT03990649 - Study of TAK-935 as an Adjunctive Therapy in Adult Participants With Complex Regional Pain Syndrome (CRPS) Phase 2
Recruiting NCT03616262 - "Efficacy of Botulinum Toxin Injection in Reducing Limb Pain in Patients With Complex Regional Pain Syndrome" Early Phase 1
Active, not recruiting NCT02504008 - CREATE-1: A Study to Assess the Efficacy and Safety of AXS-02 in Patients With CRPS-1 Phase 3
Completed NCT03879538 - Nitrous Oxide for the Treatment of Complex Regional Pain Syndrome Phase 3
Terminated NCT03794024 - Comparison of Dorsal Column Stimulation to Dorsal Root Ganglion Stimulation for Complex Regional Pain Syndrome
Terminated NCT00780390 - Autonomic Dysfunction and Spinal Cord Stimulation in Complex Regional Pain Syndrome N/A
Completed NCT00904202 - A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Phase 4
Recruiting NCT05197959 - Treatment of Complex Regional Pain Syndrome N/A
Completed NCT02753101 - [18F]FTC-146 PET/MRI in Healthy Volunteers and in CRPS and Sciatica Early Phase 1
Withdrawn NCT00414804 - Spinal Cord Stimulation Versus Nerve Blocks and Physical Therapy N/A
Completed NCT02972359 - Safety of Intravenous Neridronic Acid in CRPS Phase 3