Complex Regional Pain Syndrome I of Lower Limb Clinical Trial
Official title:
Prevention of Complex Regional Pain Syndrome Using Liposomal Encapsulated Vitamin C in Programmed Knee Surgery; A Prospective Randomized Trial
Abstract:
Complex regional pain syndrome (CRPS) is a significant complication in operated
osteoarticular pathology and may adversely affect patient's quality of life. Vitamin C is an
anti-oxidant and a neuro-modulating agent. Intake of vitamin C appears to be the only
preventative factor. The objective of this study seeks to assess the effectiveness of
liposomal conditioning of vitamin-C in reducing CRPS and to show evidence that it is more
effective than taking vitamin C in its usual form.
Methods:
Three series of patients undergone for identical pathologies the same surgery performed in
the same centre by a single surgeon using the same operative techniques and the same
implants. The first group took vitamin C in liposomal form. The second one took classical
vitamin C tablets while the third one received placebo pills. Comparison was made between
both groups which were identical in number and were the same average age. Results were
compared and analysed at the end of one-year follow-up.
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