Community-acquired Pneumonia Clinical Trial
Official title:
Use of Corticosteroids in Children Hospitalized With Community-acquired Pneumonia
The purpose of this study is to determine the efficacy of addition of corticosteroid therapy
to antibiotics in children hospitalized with community-acquired pneumonia.
The hypothesis is that the use of corticosteroids decreases the length of stay in children
hospitalized with community-acquired pneumonia.
Community-acquired pneumonia (CAP) is a common problem in pediatric practice. The lower
respiratory tract infections, particularly pneumonia, are a frequent cause of morbidity in
children and is the leading cause of mortality in developing countries.
In the last 20 years, despite several research, only a small decrease in morbidity and
mortality has been achieved.
Corticosteroids have an immune-modulation effect, not completely elucidated. Most likely,
this effect is due to down regulation of pro-inflammatory cytokines.
We postulate that adding corticosteroids to antibiotic treatment of CAP might change the
immune response and thereby reduce morbidity, leading to a decrease in patients hospital
length of stay.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment
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