Colorectal Cancer Clinical Trial
Official title:
In Vivo Study to Determine the Efficacy of Sentinel Node Mapping in Patients With Colon Carcinoma Using Near-infrared Laparoscopy
The sentinel lymph node (SLN) procedure is a standard staging technique in several types of
cancer. One of the major problems of SLN mapping in colorectal cancer is the lack of an
optimal dye and technique for identification of the nodes. In this study the investigators
used the Near-Infrared (NIR) dye Indocyanin Green (ICG) to identify nodes with a newly
developed NIR laparoscope. The investigators compared two different injection techniques;
subserosal and submucosal injection.
Patients planned for a laparoscopic resection of a colorectal carcinoma without distant
metastases were included. Dye was injected in the subserosa or submucosa of the bowel. Ten
minutes after injection the investigators searched for fluorescent nodes with the NIR
laparoscope. Fluorescent nodes were harvested and analyzed by the pathologist using H&E and
additional immunohistochemistry.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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