Clinical Trials Logo

Clinical Trial Summary

In this study, the investigators will investigate the cognitive effects of fenfluramine, a drug that directly stimulates the release of serotonin in the brain and positively modulates σ1 function. The investigators will use fenfluramine to assess the cognitive effects of modulating serotonin and σ1 function in healthy volunteers using a battery of cognitive tasks that measure learning and memory, executive functioning, reward processing, and emotional processing. The study design is double-blind, and participants will be randomised to either seven days of fenfluramine or placebo administration. All participants will attend two screening visits to assess eligibility. There are two main study visits; during the first, participants will undertake cognitive tasks and questionnaires before taking the initial study dose. One the second study visit, participants will once again complete these tasks and questionnaires after a week of fenfluramine/placebo administration.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05026398
Study type Interventional
Source University of Oxford
Contact
Status Completed
Phase Phase 4
Start date April 12, 2021
Completion date June 22, 2022

See also
  Status Clinical Trial Phase
Recruiting NCT05563805 - Exploring Virtual Reality Adventure Training Exergaming N/A
Completed NCT03708692 - Menstrual Cycle Phases on Recovery and Cognitive Function
Active, not recruiting NCT04505345 - Virtual Reality Cognitive Training in Alcohol Use Disorder N/A
Completed NCT04430465 - Effects of Wholegrains on Children's Health (KORN) N/A
Completed NCT02915913 - Effects of Exercise Training on Cognitive Function and Neurotrophic Factors in Overweight Adults N/A
Completed NCT01410097 - Physical and Cognitive Function - Look AHEAD Ancillary Study N/A
Completed NCT03826121 - Efficacy and Safety of Sesame Oil Cake Extract on Improvement of Cognitive Function N/A
Recruiting NCT05621278 - Children to Adults Mental and Psychosomatic Health Study (CAMPS)
Completed NCT05498415 - Feasibility, Acceptability, and Efficacy of the Sleep Move Stand Study N/A
Completed NCT03208569 - Anticholinergic Burden - Treatment Optimization
Completed NCT03793777 - The Effect of Aronia Melanocarpa Extract on Cognitive Function N/A
Recruiting NCT05525299 - Reminiscence-Based Life Review on Copying With Existential Suffering Among Older Cancer Survivors N/A
Completed NCT03698123 - Performance Nutrition for Residents and Fellows N/A
Completed NCT04543500 - Self-regulation of Prefrontal Cortex During Emotional Cognitive Control N/A
Recruiting NCT05891977 - Effect of Tomato Paste Consumption on the Microbiota-gut-brain Axis in Healthy Adults N/A
Recruiting NCT05591885 - Nutrilite Memory Builder on the Improvement of Cognitive Function N/A
Active, not recruiting NCT05575752 - Acute Health Effects of High Temperature Exposure N/A
Completed NCT03716609 - Effects of Magnesium Supplementation on Hemodynamic Parameters and Cognitive Function N/A
Completed NCT02763514 - The Effects of DHA- and EPA-enriched Oils on Cognitive Function and Mood N/A
Completed NCT02675621 - Investigation of Acute Mood and Cognitive Performance Effects of Beverages Containing Phenolics in Healthy Adults N/A