Interactive Stepping Exercise on Memory

Cognitive Function Clinical Trial

Official title:

Effects of Interactive Stepping Exercise on Memory in Adults With Amnestic Mild Cognitive Impairment

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04103463
• Other study ID #: YM108072F
• Status: Not yet recruiting
• Phase: N/A
• Start date: October 1, 2019
• Est. completion date: July 31, 2021

Study information

• Verified date: September 2019
• Source: National Yang Ming University
• Contact: Yea-Ru Yang
• Phone: +886228267279
• Email: yryang[@]ym.edu.tw
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This is a randomized controlled trail. A total of 28 individuals with aMCI will be randomly assigned to either the ISE group or control group. The ISE intervention conducts three times a week for 16 weeks. Outcomes are measured at baseline and after intervention. The primary outcomes are the Chinese version verbal learning test (CVVLT), selective reminding test (SRT), and logic memory test (Wechsler Memory Scale). The secondary outcomes are Montreal Cognitive Assessment (MoCA) for cognitive function, and trail making test Part A & B (TMT-A & B), Stroop test, and 25-item Executive Interview (C-EXIT 25) for executive function.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 30
• Est. completion date: July 31, 2021
• Est. primary completion date: December 31, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 50 Years to 100 Years

Eligibility

Inclusion Criteria:

• Age=50 years

• Complained of memory impairment

• Chinese Version Verbal Learning Test 10-minute delays = 6 words

• MMSE score=24 and CDR score=0.5

• Activities of daily living are intact

• DSM-IV criteria for the diagnosis of dementia is not met

Exclusion Criteria:

• Any significant neurologic disease other than suspected incipient Alzheimer's disease

• Psychotic features, contraindication of exercise... which could lead to difficulty complying with the protocol

Related Conditions & MeSH terms

• Amnestic Mild Cognitive Impairment
• Cognitive Dysfunction
• Cognitive Function
• Executive Function
• Interactive Stepping Exercise
• Memory

Intervention

Other:
• Interactive stepping exercise
An exercise intervention based on the principle of square stepping exercise
• Home exercise
Home exercise

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
National Yang Ming University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Chinese version verbal learning test		Change from baseline at 12 week
Primary	Selective reminding test		Change from baseline at 12 week
Primary	Wechsler Memory Scale-III		Change from baseline at 12 week
Primary	Logic memory test		Change from baseline at 12 week
Secondary	Montreal Cognitive Assessment		Change from baseline at 12 week
Secondary	Trail making test		Change from baseline at 12 week
Secondary	Stroop test		Change from baseline at 12 week
Secondary	Executive Interview		Change from baseline at 12 week