Surgery Clinical Trial
Official title:
Cerebrovascular Autoregulation During Major Non-cardiac Surgery and Risk for Postoperative Cognitive Dysfunction in Elderly Patients
Cerebral blood flow is tightly regulated to ensure constant cerebral perfusion independently
from systemic blood pressure fluctuations. This mechanism is termed cerebrovascular
autoregulation and preserves adequate cerebral perfusion in a range between 50 and 150 mmHg
of cerebral perfusion pressure. Upper and lower autoregulatory limits may vary individually.
Beyond the autoregulatory range the protective autoregulatory response is lost, facilitating
cerebral ischemia or hyperemia.
The cerebrovascular response may be altered during general anesthesia, through direct effects
of anesthetic agents on the vascular tone, changes of arterial partial pressure of carbon
dioxide or the administration of vasoactive substances. The association of perioperative
impairment of cerebral autoregulation and postoperative cognitive function has been discussed
controversially.
- continuous monitoring of cerebrovascular autoregulation using the correlation method
- based on near-infrared spectroscopy and invasive blood pressure measurement an index
(COx) will be calculated
- autoregulation monitoring from anesthesia induction until emergence from anesthesia
- assessment of preoperative cognitive function during preanesthesia evaluation or on the
day before surgery
- assessment of postoperative cognitive function between day 3 and 14 following surgery
- evaluation of subjective cognitive complaints or attention deficits 3 months after
surgery
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05583916 -
Same Day Discharge for Video-Assisted Thoracoscopic Surgery (VATS) Lung Surgery
|
N/A | |
| Completed |
NCT03213314 -
HepaT1ca: Quantifying Liver Health in Surgical Candidates for Liver Malignancies
|
N/A | |
| Enrolling by invitation |
NCT05534490 -
Surgery and Functionality in Older Adults
|
N/A | |
| Recruiting |
NCT04792983 -
Cognition and the Immunology of Postoperative Outcomes
|
||
| Recruiting |
NCT04612491 -
Pre-operative Consultation on Patient Anxiety and First-time Mohs Micrographic Surgery
|
||
| Recruiting |
NCT04444544 -
Quality of Life and High-Risk Abdominal Cancer Surgery
|
||
| Completed |
NCT04204785 -
Noise in the OR at Induction: Patient and Anesthesiologists Perceptions
|
N/A | |
| Completed |
NCT03432429 -
Real Time Tissue Characterisation Using Mass Spectrometry REI-EXCISE iKnife Study
|
||
| Completed |
NCT04176822 -
Designing Animated Movie for Preoperative Period
|
N/A | |
| Recruiting |
NCT05370404 -
Prescribing vs. Recommending Over-The-Counter (PROTECT) Analgesics for Patients With Postoperative Pain:
|
N/A | |
| Not yet recruiting |
NCT05467319 -
Ferric Derisomaltose/Iron Isomaltoside and Outcomes in the Recovery of Gynecologic Oncology ERAS
|
Phase 3 | |
| Recruiting |
NCT04602429 -
Children's Acute Surgical Abdomen Programme
|
||
| Completed |
NCT03124901 -
Accuracy of Noninvasive Pulse Oximeter Measurement of Hemoglobin for Rainbow DCI Sensor
|
N/A | |
| Completed |
NCT04595695 -
The Effect of Clear Masks in Improving Patient Relationships
|
N/A | |
| Recruiting |
NCT06103136 -
Maestro 1.0 Post-Market Registry
|
||
| Completed |
NCT05346588 -
THRIVE Feasibility Trial
|
Phase 3 | |
| Completed |
NCT04059328 -
Novel Surgical Checklists for Gynecologic Laparoscopy in Haiti
|
||
| Recruiting |
NCT03697278 -
Monitoring Postoperative Patient-controlled Analgesia (PCA)
|
N/A | |
| Completed |
NCT03355547 -
Observation of Atelectasis Using Lung Ultrasonography in Children Undergoing General Anesthesia: the Cohort Study for Evaluation of the Relationship Between the Incidence and Severity of Upper Respiratory Tract Infection and the Magnitude of Anesthesia-induced Atelectasis
|
||
| Recruiting |
NCT04776954 -
Comparison of Normothermia Maintenance Between Resistive Blanket and Forced Air Warming Systems in Renal Transplant Surgery
|
N/A |