Cocaine-Related Disorders Clinical Trial
Official title:
Impulsivity, Brain Function and Substance Abuse Treatment
Cocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found. The purpose of this trial is to evaluate aspects of treatment response in cocaine dependent individuals.
Cocaine is a strong central nervous system stimulant that is widely abused throughout the
United States. Due to its widespread use, it is important to develop an effective treatment
for cocaine dependence. The purpose of this study is to determine how impulsivity and
prefrontal cortical function are related to treatment response in cocaine dependent
individuals.
Participants in this study will complete four separate experiments, each with a different
aim and testing panel [cognitive function tests with and without functional magnetic
resonance imaging (fMRI)]. The first experiment will examine memory, attention, cognitive
function, and impulsivity; the aim is to determine the relationship between impulsivity and
cognitive function in cocaine dependent individuals receiving treatment. The second
experiment will examine the relationship between impulsivity and the prefrontal cortical
structure and function. Participants will complete an fMRI during the second experiment. The
third experiment will consist of cognitive function tests and will examine the prefrontal
cortex in relation to treatment response, based on four different treatments: 1) L-dopamine,
2) naltrexone, 3) modafinil, and 4) placebo. The fourth experiment will examine the effect
of cocaine dependence treatment on prefrontal cortex, focusing on participants receiving
modafinil.
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