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A Study of the Relationship Between Disulfiram and Cocaine Self-administration.

Cocaine Addiction Clinical Trial

Official title:
Laboratory Models of Cocaine Self-administration

Clinical Trial Summary

The problem of cocaine dependence remains a major medical, social, and legal concern. Several studies have suggested that disulfiram may be beneficial for the treatment of cocaine dependence. A common assumption has been that disulfiram treatment, by increasing DA availability, enhances the aversive aspects of stimulants. This study aims to measure plasma activity in those with the C/C DBH genotype, which is associated with higher DBH activity subsequently making the disulfiram treatment more effective, as well as determine the effects of treatment with disulfiram on cocaine self-administration using a human laboratory model of cocaine self-administration.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00729300
Study type Interventional
Source Baylor College of Medicine
Contact
Status Completed
Phase Phase 1/Phase 2
Start date April 2006
Completion date June 2016
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