Cigarette Smoker Clinical Trial
Official title:
Enhancing Relapse Prevention With rTMS: Dose-Response Parameters for Smoking Cessation
This trial studies best dose and how well repetitive transcranial magnetic stimulation (rTMS) works in promoting smoking cessation and preventing relapse in current smokers. rTMS is a form of brain stimulation therapy that controls nerve cell activity, increases blood flow in the brain, and improves cognitive function.
PRIMARY OBJECTIVES: I. To examine the effects of stimulation duration (stimulation days) and intensity (pulses per day) on outcomes among smokers (sample size [n]=258) motivated to quit. II. To identify the most promising dosing strategy by balancing effect sizes and undesirable effects. III. To examine the effects of 16 20Hz rTMS sessions combined with intensive cognitive behavioral treatment and nicotine replacement on smoking cessation, developmental disability (DD rates), cognitive behavioral skill acquisition, and nicotine patch adherence among lung cancer (LC) patients (n=30). (Study 1 and Study 2) IV. To examine the feasibility and potential efficacy of 20Hz rTMS on the left dorsolateral prefrontal cortex (DLPFC) for concurrent smoking abstinence and reductions in alcohol use among smokers who are heavy drinkers (n=20). (Study 1 and Study 2) OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients undergo rTMS once daily (QD) or twice daily (BID) over 16 minutes for 8, 12, or 16 days. ARM II: Patients undergo sham rTMS QD or BID over 16 minutes for 8, 12, or 16 days. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT03691350 -
Bronchoscopy in Determining the Effect of E-Cigarette Smoking on Biomarkers in the Lungs
|
Early Phase 1 | |
| Completed |
NCT01967082 -
APPSPIRE App in Preventing Students From Smoking
|
N/A | |
| Active, not recruiting |
NCT02271919 -
Varenicline and Combined NRT for Smoking Cessation
|
Phase 4 | |
| Withdrawn |
NCT03668769 -
Quitting Schedule Mobile Smartphone Application in Helping Participants to Quit Smoking
|
N/A | |
| Completed |
NCT02575885 -
Nicotine Delivery From Novel Non-Tobacco Electronic System in Smokers
|
N/A | |
| Completed |
NCT04060446 -
Effects of Filter Ventilation on Sensory Response, Smoking Topography, and Inhalation in Current Every Day Cigarette Smokers
|
||
| Completed |
NCT00941395 -
Enhanced Smoking Cessation for University Students
|
N/A | |
| Recruiting |
NCT03199651 -
Beating Lung Cancer in Ohio Protocol in Improving Survival in Patients With Stage IV Non-Small Cell Lung Cancer
|
N/A | |
| Recruiting |
NCT03824535 -
18F-FSPG PET/CT in Diagnosing Early Lung Cancer in Patients With Lung Nodules
|
Phase 2 | |
| Completed |
NCT00468234 -
Validation of Biomarkers of Exposure and Host Response
|
N/A | |
| Completed |
NCT00850954 -
Project CASA in Promoting Smoke-Free Indoor Air Policy in Mexican American Households
|
N/A | |
| Active, not recruiting |
NCT02697227 -
Behavioral Activation Therapy and Nicotine Replacement Therapy in Increasing Smoking Cessation
|
N/A | |
| Completed |
NCT03669120 -
Tailored Smoking Cessation Intervention in Promoting Sexual and Gender Minority Smokers to Quit Smoking
|
N/A | |
| Completed |
NCT00948129 -
Mobile Smoking Cessation Intervention in Enhancing Cancer Outreach in Low-Income Adult Smokers
|
N/A |