| Eligibility |
Inclusion Criteria:
1. Men and women aged 40-70 years (both inclusive)
2. Type 2 diabetes mellitus on stable hypoglycemic therapy for >1 month
3. Diagnosed with heart failure* according to 2016 ESC Guidelines for Chronic Heart
Failure for at least 6 months and receiving SoC for at least 3 months
*HF - a clinical syndrome characterized by typical symptoms (e.g. breathlessness,
ankle swelling and fatigue) that may be accompanied by signs (e.g. elevated jugular
venous pressure, pulmonary crackles and peripheral edema) caused by a structural
and/or functional cardiac abnormality, resulting in a reduced cardiac output and/or
elevated intra-cardiac pressures at rest or during stress
4. Participants with LVEF =40% including HFpEF according to ESC criteria, diagnosed by
ECHO, confirmed by core ECHO laboratory AND having moderate to severe diastolic
dysfunction as described in 'Classification of Diastolic Dysfunction'
5. NT-proBNP (N-terminal fragment of brain natriuretic peptide) 250-3500 pg/mL (both
inclusive) For participants who have atrial fibrillation, the inclusion qualification
would be 750- 3500 pg/ml (both inclusive)
6. Treatment with stable# doses of loop diuretics for >1 month at a daily dose of
furosemide of =40 mg or equivalent (1 mg of bumetanide or 10 mg of torasemide) or
alternatively, 20 mg furosemide + mineralocorticoid receptor antagonist or equivalent
(0.5 mg of bumetanide + mineralocorticoid receptor antagonist or 5 mg of torasemide +
mineralocorticoid receptor antagonist) or equivalent as per the regional SoC
7. On stable# doses of beta-blockers for >1 month
- No exceptions are allowed to the above rule if LVEF is =50% OR the patient has
coronary artery disease,
- If LVEF is >50% and the patient is NOT KNOWN to have coronary disease, they may
be included if they are not taking beta-blockers provided there is no indication
to use them such as rate control for atrial fibrillation or hypertension
8. Participants willing to give written informed consent (prior to any study-related
procedures being performed) and able to adhere to the study restrictions and
assessments schedule
- stable = a dose no lower than half the current dose and not greater than double
the current dose
Exclusion Criteria:
1. Known hypersensitivity to any ingredient of the study medication
2. Heart failure caused by myocarditis, cor-pulmonale, congenital heart
disease,constrictive pericarditis, idiopathic hypertrophic or restrictive
cardiomyopathy, amyloid heart disease or rheumatic heart disease
3. Significant valvular heart disease including severe mitral regurgitation or left
ventricular (LV) aneurysm as judged by the investigator and/or echo core-laboratory
4. History of MI, CABG surgery, PCI or other major surgery, stroke or TIA in past 6
months
5. Patients who are anticipated to require coronary revascularization; patients with
angina must be evaluated by a cardiologist to determine the need for revascularization
6. NYHA class IV
7. A score of less than 12 points on adequately explained and administered MLHFQ points
2, 3, 4, 5, 7, 8, 12 and 13
8. Hospitalization for heart failure with overnight stay in the past 3 months
9. Participants with symptomatic or sustained VT* in the past 6 months and planned for
cardiac resynchronization therapy (CRT) or implantation of ICD for the duration of the
study.
* Participant with symptomatic or sustained VT having an implantable cardioverter
defibrillator (ICD) can be included in the study.
10. Atrial fibrillation or flutter with a resting ventricular rate >110 beats per minute
11. Unable to walk or has any contraindication to 6-minute walk test or those in whom
longest distance walked in supervised 6 minutes (6MWTD) at baseline was <100 m or
>350m
12. Systolic BP < 100 mmHg or = 160 mmHg or Diastolic BP = 100 mmHg at screening
13. Hb <12 g/dL
14. HbA1c >11%
15. eGFR <30 mL/min/1.73m2 (calculated by Modification of Diet in Renal Disease formula)
[eGFR (mL/min/1.73 m²) = 175 × (Scr)-1.154 × (Age)-0.203 × (0.742 if female) × (1.212
if African American) (conventional units)]
16. Liver enzymes (AST or ALT) exceeding 3 times the upper limit of normal range at
screening and considered clinically significant by the investigator
17. Current hyponatremia (Na+ <130 mmol/L) or hyperkalemia (K+ >5.5 mmol/L)
18. Participants on insulin as monotherapy for diabetes
19. History of gastrointestinal disorder (e.g. malabsorption syndrome) that could
interfere with study drug absorption
20. Known to have positive test for HIV, Hepatitis B, Hepatitis C at the time of screening
21. History of malignancy in last 3 years other than basal cell carcinoma
22. Pregnant or lactating women, or female of childbearing potential, who are neither
surgically sterilized nor willing to use reliable contraceptive methods (double
barrier methods or intrauterine device)
23. Men with partners of childbearing potential not willing to use reliable contraception
methods
24. Current participation (including prior 30 days) in any other therapeutic clinical
trial
25. In the opinion of the investigator, any finding which would interfere with the
objectives of the study, patient is unable to cooperate with any study procedures,
unlikely to adhere to the study procedures, keep appointments, or plan to relocate
during the study
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