Chronic Respiratory Failure Clinical Trial
Official title:
EFFECT OF EXTRACORPOREAL CO2 REMOVAL IN STABLE COPD PATIENTS WITH CHRONIC HYPERCAPNIC RESPIRATORY FAILURE:A PILOT STUDY
Chronic hypercapnic respiratory failure is common in stable COPD patients in a terminal phase
of their disease In an attempt to correct or slow down the rate of rise of PaCO2, long-term
noninvasive mechanical ventilation (NIV) has been proposed.
Only very few studies demonstrated the clinical efficacy of NIV. Indeed this technique is not
always well tolerated and therefore it may be effective only in a subset of patients The aim
of this study is to assess the feasibility and safety of "one shot" extrcorporeal CO2 removal
device, in reducing the PaCO2 level
Chronic hypercapnic respiratory failure is common in stable COPD patients in a terminal phase
of their disease In an attempt to correct or slow down the rate of rise of PaCO2, long-term
noninvasive mechanical ventilation (NIV) has been proposed.
Only very few studies demonstrated the clinical efficacy of NIV. Indeed this technique is not
always well tolerated and therefore it may be effective only in a subset of patients Recently
extracorporeal CO2 removal have been shown to avoid the need of endotracheal intubation in
COPD patients with an episode of Acute Hypercapnic Respiratory Failure In this pilot
physiological study we want to assess the safety and efficacy of this technique in reducing
the PaCO2 level in those COPD patients with chronic hypercapnic respiratory failure non
responding to chronic NIV.
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