Chronic Pelvic Pain Syndrome Clinical Trial
Official title:
Efficacy of Electromagnetic Stimulation Therapy for the Treatment of Chronic Prostatitis or Chronic Pelvic Pain Syndrome
In 1995 the National Institutes of Health-National Institute of Diabetes and Digestive and
Kidney Diseases (NIDDK) workshop reached a consensus on the definition and classification of
prostatitis syndromes.The commonest and yet most poorly understood of these prostatitis
syndromes is category III or chronic pelvic pain syndrome (CPPS). It has been shown that,
while men with CPPS have significantly higher leukocyte counts in urine and expressed
prostatic secretions compared with age matched controls, inflammation and infection do not
necessarily correlate with symptom severity.
The lack of a direct relationship between inflammation and symptoms is supported through
studies of prostate histopathology, in which moderate or severe inflammation was identified
in only 5% of men with CPPS.Conventional treatment has focused on long, empirical courses of
expensive broad-spectrum antibiotics, mostly of the quinolone class, with or without the
concomitant use of an α-blocker and anti-inflammatory agents. At the turn of the 19th
century stimulation with electrical current and changing magnetic fields was used to treat
surface conditions associated with intractable pain, such as painful malignant ulcers. The
analgesic benefits of pulsed electromagnetic fields for relieving pelvic pain has been
investigated in women with tissue trauma and chronic refractory pelvic pain.Despite its
uncertain etiology there is some evidence that the symptom complex found in CPPS may be
founded at least in part in pelvic floor muscular dysfunction and/or neurogenic
hypersensitivity/inflammation.
We hypothesized that the application of a electromagnetic stimulation to the perineum of the
subject may result in neural excitation and pelvic floor muscle stimulation to a degree that
breaks the cycle of tonic muscular spasm and neural hypersensitivity/inflammation, thereby,
restoring more normal pelvic floor muscular activity.
n/a
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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