Assessment of Response to the Conventional Periodontal Treatment Based on the Blood Group Phenotypes.

Chronic Periodontitis Clinical Trial

Official title:

Investigating the Role of ABO Blood Group in the Response to the Nonsurgical Periodontal Treatment.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03644901
• Other study ID #: UDDS-Perio-03-2018
• Status: Completed
• Start date: January 15, 2018
• Est. completion date: March 10, 2019

Study information

• Verified date: March 2019
• Source: Damascus University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of this study is to find out if one blood group phenotype is more responsive than the others to the nonsurgical periodontal treatment.

Description:

To the best of our knowledge, this is the first (research) randomized clinical trial that assesses how patient respond to the nonsurgical periodontal treatment based on their blood group phenotype.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: March 10, 2019
• Est. primary completion date: October 1, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 60 Years

Eligibility

Inclusion Criteria:

• systematically healthy.

• have at least 20 teeth excluding the third molars.

• had not received any periodontal treatment or antibiotic therapy for dental or medical reason 6 month prior to the study.

• diagnosed with generalized chronic periodontitis (>30% of the sites have probing depth =4), and a minimum of six teeth with probing depth of 5-6 mm.

Exclusion Criteria:

• smokers and alcoholics.

• pregnancy.

• history of a systematic disease such as diabetes, leukemia, epilepsy.

• participants who are unable to perform routine oral hygiene.

• use of orthodontic appliances.

• participants who are unable to perform routine oral hygiene.

Related Conditions & MeSH terms

• Chronic Periodontitis
• Periodontitis

Intervention

Procedure:
• nonsurgical periodontal treatment
patients will undergo nonsurgical periodontal treatment to reduce the relative attachment level and improve the probing depth. An initial session will be conducted to remove supra gingival plaque and calculus. another appointment is set to perform full moth scalling and root planing.

Locations

Country	Name	City	State
Syrian Arab Republic	Department of Periodontics	Damascus

Sponsors (1)

Lead Sponsor	Collaborator
Damascus University

Country where clinical trial is conducted

Syrian Arab Republic, 

References & Publications (5)

Demir T, Tezel A, Orbak R, Eltas A, Kara C, Kavrut F. The Effect of ABO Blood Types on Periodontal Status. Eur J Dent. 2007 Jul;1(3):139-43. — View Citation

Gautam A, Mittal N, Singh TB, Srivastava R, Verma PK. Correlation of ABO Blood Group Phenotype and Rhesus Factor with Periodontal Disease: An Observational Study. Contemp Clin Dent. 2017 Apr-Jun;8(2):253-258. doi: 10.4103/ccd.ccd_307_17. — View Citation

Pai GP, Dayakar MM, Shaila M, Dayakar A. Correlation between "ABO" blood group phenotypes and periodontal disease: Prevalence in south Kanara district, Karnataka state, India. J Indian Soc Periodontol. 2012 Oct;16(4):519-23. doi: 10.4103/0972-124X.106892. — View Citation

Wang W, Liu L, Wang Z, Wei M, He Q, Ling T, Cao Z, Zhang Y, Wang Q, Shi M. Impact of ABO blood group on the prognosis of patients undergoing surgery for esophageal cancer. BMC Surg. 2015 Sep 29;15:106. doi: 10.1186/s12893-015-0094-1. — View Citation

Yu Q, Wang L, Zhang S, Feng T, Li L, Chen B, Chen M. The role of ABO blood groups in Crohn's disease and in monitoring response to infliximab treatment. Blood Transfus. 2016 Sep;14(5):460-4. doi: 10.2450/2016.0199-15. Epub 2016 Feb 24. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in relative attachment level.	the relative attachment level measures the length form the base of the periodontal pocket to a stent	measures will be taken at baseline and after two months from treatment.
Secondary	Change in periodontal probing depth.	the distance between the gingival margin to the base of the periodontal pocket.	measures will be taken at baseline and after two months from treatment.
Secondary	Change in gingival index	it is used to designate the level of the gingival inflammation.	index will be taken at baseline and after two months from treatment.
Secondary	Change in plaque Index	it is used to designate the level of plaque accumulation.	index will be taken at baseline and after two months from treatment.