Alterations in Subgingival Microbiota and Hypoxia in Occlusal Trauma

Chronic Periodontitis Clinical Trial

Official title:

Alterations in Subgingival Microbiota and Hypoxia in Occlusal Trauma

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03621891
• Other study ID #: balciyuce84
• Status: Completed
• Start date: May 1, 2016
• Est. completion date: May 1, 2017

Study information

• Verified date: August 2018
• Source: Tokat Gaziosmanpasa University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Present study suggests that excessive occlusal forces did not cause a significant change in hypoxia and vascular markers, however a slight alteration in subgingival microbiota was observed.

Description:

Occlusal trauma is defined as tissue destruction and/or injury resulting in tissue changes in the periodontium as a consequence of excessive occlusal forces or hyper-occlusion. Previous studies suggested accelerated periodontal destruction around teeth with occlusal trauma and increased mobility, however, the evidence is lacking. Recent animal studies found that occlusal trauma increased osteoclastic activity and alveolar bone loss. One possible mechanism suggested for the progression of periodontal destruction with occlusal trauma is that tooth mobility creates a subgingival environment conducive to overgrowth by periodontal pathogens. However, the association of occlusal trauma and subgingival microbiota was not evaluated in previous studies. Therefore, present study aimed to evaluate subgingival dental plaque components and compare with healthy individuals and periodontitis patients without occlusal trauma.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 80
• Est. completion date: May 1, 2017
• Est. primary completion date: May 1, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 29 Years to 42 Years

Eligibility

Inclusion Criteria:

• Systemical health

• No drug use

• No pregnancy or lactation For group 3 and 4;

• Bruxism at least for 2 years

• Occlusal trauma

• Existence of at least 20 functioning teeth

Exclusion Criteria:

• Smoking

• Pregnancy/lactation

• Systemical disease

• Drug use

• Absence of at least 20 functioning teeth

Related Conditions & MeSH terms

• Chronic Periodontitis
• Hypoxia
• Occlusal Trauma
• Periodontitis
• Wounds and Injuries

Locations

Country	Name	City	State
Turkey	Gaziosmanpasa University	Tokat
Turkey	Gaziosmanpasa University Faculty of Dentistry	Tokat

Sponsors (1)

Lead Sponsor	Collaborator
Tokat Gaziosmanpasa University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Determination of certain bacterial species in subgingival dental plaque	Subgingival dental plaque samples were collected from each participant and evaluated via polymerase-chain reaction.	A day after initial examination
Secondary	hypoxic changes in gingiva and serum	Determination of the hypoxia inducible factor-alpha and vascular endothelial growth factor via ELISA	One day after initial examination