Chronic Periodontitis Clinical Trial
Official title:
Comparative Evaluation of Locally Delivered 1.2% Atorvastatin and 1.2% Rosuvastatin Gel in Treatment of Mandibular Degree ii Furcation Defects in Chronic Periodontitis Subjects: A Randomized Controlled Clinical Trial
Statins are one of the lipid lowering drugs that help in reducing cholesterol levels in the body by specifically inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase; which is a rate limiting enzyme for cholesterol synthesis. Rosuvastatin (RSV) and atorvastatin (ATV) have shown to have bone stimulatory and anti-inflammatory effects.. The present study aims to explore the efficacy of 1.2% RSV and 1.2% ATV gel as a local drug delivery and redelivery system as an adjunct to scaling and root planing (SRP) for the treatment of degree II furcation defects.
Statins are one of the lipid lowering drugs that help in reducing cholesterol levels in the
body by specifically inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase; which is a
rate limiting enzyme for cholesterol synthesis. Rosuvastatin (RSV) and atorvastatin (ATV)
have shown to have bone stimulatory and anti-inflammatory effects.. The present study aims
to explore the efficacy of 1.2% RSV and 1.2% ATV gel as a local drug delivery and redelivery
system as an adjunct to scaling and root planing (SRP) for the treatment of degree II
furcation defects.
Methods: Ninety patients with mandibular buccal class II furcation defects were randomly
allocated into three treatment groups: SRP plus placebo gel (group 1), SRP plus 1.2% RSV gel
(group 2) and 1.2% ATV gel (group3). Clinical and radiographic parameters were recorded at
baseline then after 6 months. The gels were redelivered at the respective sites at this 6
month appointment. Then again all clinical and radiographic parameters were recorded after 3
months. (9 months from baseline)
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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