Chronic Periodontitis Clinical Trial
Official title:
1.2% Rosuvastatin Versus 1.2% Atorvastatin Local Drug Delivery in Treatment of Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical Trial
The present study is designed as a single-centre, randomized, controlled clinical trial to evaluate and compare the clinical and radiographic efficacy of two local drug delivery systems containing 1.2% RSV gel and 1.2% ATV gel in treatment of intrabony defects in patients with chronic periodontitis as an adjunct to SRP.
Background: Rosuvastatin (RSV) and Atorvastatin (ATV) are known to inhibit osteoclastic bone
resorption and were proposed to have osteostimulative properties by causing osteoblast
differentiation in vivo and in vitro as shown by an increase in matrix formation. The aim of
the present study is to evaluate and compare the efficacy of 1.2% RSV and 1.2% ATV gel as
local drug delivery systems in adjunct to scaling and root planning (SRP) for the treatment
of intrabony defects in patients with chronic periodontitis (CP).
Methods: A total of 90 intrabony defects were treated with either 1.2% RSV, 1.2% ATV or
placebo gel LDD after SRP. Clinical parameters (plaque index, modified sulcus bleeding
index, probing depth and clinical attachment level) were recorded at baseline and 6 months.
Radiographic intrabony defect depth change was calculated on standardized radiographs by
using image analysis software at 6 months.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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