Chronic Periodontitis Clinical Trial
Official title:
Comparison Of Efficacy Of Locally Delivered 1.2% Simvastatin And 1% Metformin Gel In Chronic Periodontitis: A Randomized Placebo Controlled Clinical Trial
This randomized controlled clinical trial compares efficacy of 1.2% simvastatin with 1% metformin in chronic periodontitis subjects.
Aim: To compare the efficacy of locally delivered 1.2% SMV gel and 1% MF gel in treatment of
intrabony defects in chronic periodontitis subjects and compare it with placebo gel.
Methods: Ninety subjects were categorized into three treatment groups: 1.2% Simvastatin
(SMV), 1% Metformin (MF) and placebo gel after Scaling and root planning (SRP). Clinical
parameters were recorded at baseline, 3, 6 and 9 months; they included plaque index (PI),
modified sulcus bleeding index (mSBI), pocket probing depth (PPD), and clinical attachment
level (CAL). Radiologic assessment of intra bony defect (IBD) and percentage defect depth
reduction (DDR%) was done at baseline, 6 months and 9 months interval using computer-aided
software
Results: Mean PPD reduction and mean CAL gain was found to greater in SMV group than MF and
placebo group at all visits. The DDR% was greater in SMV group as compared to MF and placebo
group.
Conclusion: There was greater decrease in mSBI and PPD and more CAL gain with significant
IBD depth reduction at the sites treated with SMV and MF as an adjunct to SRP in chronic
periodontitis subjects with intrabony defects as compared to placebo. The effect was greater
in case of SMV group, however there was no significant defect depth reduction as compared to
MF.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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