Chronic Periodontitis Clinical Trial
Official title:
Using Chemical Pocket Disinfection as an Adjunct to Non-surgical Maintenance Therapy of Inflamed Periodontal Pockets
Verified date | August 2023 |
Source | University of Nebraska |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This study will determine whether the supplemental use of chemical pocket disinfection with scaling and root planing is more effective than scaling and root planing alone in clinically reducing periodontal probing depth (PD), reducing bleeding on probing (BOP), and gaining clinical attachment level (CAL). It also will assess whether chemical pocket disinfection with scaling and root planing will have an effect on biomarkers of inflammation.
Status | Terminated |
Enrollment | 33 |
Est. completion date | November 22, 2016 |
Est. primary completion date | November 22, 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 30 Years and older |
Eligibility | Inclusion Criteria: - Periodontal maintenance patients, have at least one pocket greater than or equal to 5 mm with bleeding on probing Exclusion Criteria: - Uncontrolled diabetics - Regular users of nonsteroidal antiinflammatory drugs - Individuals on anti-coagulants - Individuals that have used antibiotics in the previous 3 months or require prophylactic antibiotic coverage - Pregnant individuals |
Country | Name | City | State |
---|---|---|---|
United States | UNMC College of Dentistry | Lincoln | Nebraska |
Lead Sponsor | Collaborator |
---|---|
University of Nebraska |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Probing depths | Periodontal probing depth (PD) | 3 months | |
Secondary | Bleeding on probing | Incidence of bleeding during probing | 3 months | |
Secondary | Clinical attachment level | Clinical attachment level is calculated by adding gingival recession to probing depth; measures the connective tissue and epithelial attachment level relative to the cementoenamel junction | 3 months | |
Secondary | Inflammatory markers | Measure interleukin-1 beta and interleukin 1 receptor antagonist levels in gingival crevicular fluid from sites of interest | 3 months |
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