Chronic Periodontitis Clinical Trial
Official title:
COMPARATIVE EVALUATION OF CLINICAL EFFICACY OF SUBGINGIVALLY DELIVERED 1.2% ATORVASTATIN AND 1.2% SIMVASTATIN IN TREATMENT OF CHRONIC PERIODONTITIS: A RANDOMIZED CONTROLLED TRIAL
Background: Statins are the recently evolved agents that aid in periodontal regeneration and
ultimately attaining periodontal health. Atorvastatin (ATV) and Simvastatin (SMV) are
specific competitive inhibitors of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. The
present study was designed to evaluate and compare the effectiveness of 1.2% ATV, and 1.2%
SMV as an adjunct to scaling and root planing (SRP) in the treatment subjects with chronic
periodontitis.
Methods: Ninety six subjects were categorized into three treatment groups: SRP plus 1.2%
ATV, SRP plus 1.2% SMV and SRP plus placebo. Clinical parameters; full mouth plaque index
(PI), modified sulcus bleeding index (mSBI), probing depth (PD), and relative attachment
level (RAL) were recorded at baseline before SRP and at 3, 6 and 9 months. Percentage
radiographic defect depth reduction was evaluated using computer-aided software at baseline,
6 months and 9 months.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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