Role of Infected Blood Dendritic Cells in Heart Disease Risk

Status Completed

Clinical Trial Summary

The investigators hypothesize that blood dendritic cells harbor pathogens from the oral cavity in chronic periodontitis and disseminate these pathogens to atherosclerotic plaques.

Clinical Trial Description

To address this hypothesis, a clinical study in humans with moderate to severe chronic periodontitis has been designed. This is an interventional study involving scaling and root planing and two arms: 1. treatment with PO amoxocillin/metronidazole plus chlorhexidine oral rinse; 2. no antibiotics or oral rinse. It is expected that the antibiotics plus chlorhexidine will prevent the dendritic cell response to infection (bacteremia) elicited by scaling and root planing. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01568944
Study type	Interventional
Source	Augusta University
Contact
Status	Completed
Phase	N/A
Start date	March 2012
Completion date	September 2014

View Details

See also
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