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Neuroimaging of Opioid Phase (OPAL) — OPAL  

Chronic Pain Clinical Trial

Official title:
Neurobiological Consequences of Long-Term Opioid Therapy in the Brain and Spinal Cord

Clinical Trial Summary

The purpose of this study is to compare activity in the brains of female adults with chronic pain and/or opioid use, and healthy female adults that may help to develop new and targeted treatments for adults with chronic pain and alternatives to opioid therapy.

Clinical Trial Description

The objective of the study is to determine differences in neurophysiology and behavior during different phases of opioid use in patients. Study activities will include neuroimaging (MRI and fMRI), behavioral tasks, sensory testing, blood draws, and questionnaires. The neuroimaging data will be analyzed using specialized software; data from questionnaires, sensory testing, and behavioral task performance will be analyzed using standard statistical software. Risks and safety concerns include standard, minimal risks associated with MRI scans, sensory testing, blood draws, and confidentiality. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05905419
Study type Interventional
Source Duke University
Contact Amy Westerhoff, BS
Phone 919-684-3161
Email chronicpainresearch@duke.edu
Status Recruiting
Phase N/A
Start date June 1, 2023
Completion date June 30, 2027
View Details
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