Chronic Pain Clinical Trial
Official title:
Dynamic Assessment of Pupillary Reflex in Patients on High-dose Opioids
Evaluation of pupillary reflex in patients on high-dose opioids. Clinical assessment of pain intensity, sedation score, and other side effects of opioids. Measurements of the concentration of opioids and their active metabolites in blood.
Pupil size reflects the balance between sympathetic and parasympathetic systems. Pupil size
and reaction are also influenced by drugs, where opioids result in miosis, an effect that is
not considered to be influenced by opioid tolerance. However, cancer patients on high-dose
opioids do not always present small pupil size.
We want to perform a dynamic assessment of pupillary reflex in patients on high-dose opioids.
In addition to pupil size measurements under standard room light conditions, two pupil size
reflexes will by assessed: the pupillary light reflex when the pupil is exposed to light, and
the reflex dilation during a standardized noxious stimulus. On the same time we will assess
pain intensity, sedation score, and other side effects of opioids while measuring the
concentration of opioids and their active metabolites in blood. In addition we will register
all concomitant medication that also might influence pupil size and reaction. Patients on
more than 60 morphine equivalents pr day will be included.
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