Study of the Characteristics of Chronic Pain in Patients With Addiction

Chronic Pain Clinical Trial

— ADDICTALGO  

Official title:

Descriptive, Prospective Study of the Characteristics of Chronic Pain in Patients With Addiction to at Least One Substance

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05976178
• Other study ID #: 56LORC_2021_ADDICTALGO
• Status: Recruiting
• Start date: December 10, 2022
• Est. completion date: October 10, 2024

Study information

• Verified date: August 2023
• Source: Groupe Hospitalier de Bretagne Sud
• Contact: Alexandre Cauchie, MD
• Phone: + 33 2 97 06 72 90
• Email: a.cauchie[@]ghbs.bzh
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

It is described in the literature a higher prevalence of pain in patients with an addiction but there are few studies describing the pain profile of patients with use disorder. Pain has a very negative impact on the quality of life of opioid substituted patients. Improving knowledge on this point would make it possible to better guide specific care. The investigator proposes to conduct a single-center descriptive observational study using questionnaires, without changing the management of patients with chronic pain. The primary objective of the study is to determine the prevalence of chronic pain in patients with substance addiction hospitalized for addiction treatment.

Description:

It is described in the literature a higher prevalence of pain in patients with an addiction but there are few studies describing the pain profile of patients with use disorder. Pain has a very negative impact on the quality of life of opioid substituted patients. Improving knowledge on this point would make it possible to better guide specific care. The investigator proposes to conduct a single-center descriptive observational study using questionnaires, without changing the management of patients with chronic pain. All patients admitted to hospitalization in the addiction department of the LORIENT Hospital will be offered participation in the study. The primary objective of the study is to determine the prevalence of chronic pain in patients with substance addiction hospitalized for addiction treatment. The study will also evaluate the impact on daily activities of the presence of two chronic pathologies: chronic pain and addiction, describe the frequency of the two main psychiatric comorbidities of chronic pain: anxiety and depression, describe the different components of chronic pain in patients with substance addiction, and get information on analgesic medications.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 300
• Est. completion date: October 10, 2024
• Est. primary completion date: June 10, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• > 18 years old
• Presence of addiction to at least one substance, based on DSM-5 criteria
• Hospitalized in the addiction service of LORIENT Hospital
• Knowing how to read and write French
• Not objecting to their participation in the study after informed information

Exclusion Criteria:

• Already included during a precedent hospitalization
• Adults subject to legal protection or deprived of their liberty.

Related Conditions & MeSH terms

• Addiction
• Behavior, Addictive
• Chronic Pain

Locations

Country	Name	City	State
France	Groupe Hospitalier Bretagne Sud	Lorient

Sponsors (1)

Lead Sponsor	Collaborator
Groupe Hospitalier de Bretagne Sud

Country where clinical trial is conducted

France, 

References & Publications (5)

Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain. 2006 May;10(4):287-333. doi: 10.1016/j.ejpain.2005.06.009. Epub 2005 Aug 10. — View Citation

Larson MJ, Paasche-Orlow M, Cheng DM, Lloyd-Travaglini C, Saitz R, Samet JH. Persistent pain is associated with substance use after detoxification: a prospective cohort analysis. Addiction. 2007 May;102(5):752-60. doi: 10.1111/j.1360-0443.2007.01759.x. — View Citation

Lusted A, Roerecke M, Goldner E, Rehm J, Fischer B. Prevalence of pain among nonmedical prescription opioid users in substance use treatment populations: systematic review and meta-analyses. Pain Physician. 2013 Nov-Dec;16(6):E671-84. — View Citation

Rosenblum A, Joseph H, Fong C, Kipnis S, Cleland C, Portenoy RK. Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities. JAMA. 2003 May 14;289(18):2370-8. doi: 10.1001/jama.289.18.2370. — View Citation

Voon P, Greer AM, Amlani A, Newman C, Burmeister C, Buxton JA. Pain as a risk factor for substance use: a qualitative study of people who use drugs in British Columbia, Canada. Harm Reduct J. 2018 Jul 5;15(1):35. doi: 10.1186/s12954-018-0241-y. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Prevalence of chronic pain in patients with substance addiction hospitalized for addiction treatment.	Percentage of patients presenting with pain for more than three months among patients hospitalized in an addiction service for the management of an addiction	During the hospitalization, maximum 1 month
Secondary	Pain intensity in the last 24 hours	Results of the Brief Pain Inventory : worst and least of pain in the last 24 hours	During the hospitalization, maximum 1 month
Secondary	Interference of pain on the quality of life	Result of Brief pain inventory on general activity, mood, walking ability, normal work, relations with other people, sleep, enjoyment of life. On a scale from 0 (does not interfere) to 10 (completely interferes)	During the hospitalization, maximum 1 month
Secondary	Localisation of pain	Drawing on a diagram of a human body	During the hospitalization, maximum 1 month
Secondary	Describe the frequency of the two main psychiatric comorbidities of chronic pain: anxiety	Results of the anxiety scale of Hospital Anxiety and Depression scale. Positive if > 8. Minimum 0, maximum 21	During the hospitalization, maximum 1 month
Secondary	Describe the frequency of the two main psychiatric comorbidities of chronic pain: depression	Results of the depression scale of Hospital Anxiety and Depression scale. Positive if > 8. Minimum 0, maximum 21	During the hospitalization, maximum 1 month
Secondary	Describe the prevalence of fibromyalgia among patients with substance addiction	Results of the Fibromyalgia Rapid Screening Tool. Suspicion of fibromyalgia if >5 yes. Maximum 6 yes	During the hospitalization, maximum 1 month
Secondary	Information on analgesics medication	Collection of current analgesic medication taken every day	During the hospitalization, maximum 1 month
Secondary	Describe the prevalence of neuropathic pain among patients with substance addiction	Results of the DN3 (neuropathic pain 3). Suspicion of neuropathic pain when > 3/7	During the hospitalization, maximum 1 month