Chronic Myeloid Leukemia (CML) Clinical Trial
Official title:
Combination Study of Pioglitazone and Tyrosine Kinase Inhibitors (TKIs) in Chronic Myeloid Leukemia Patients After Failure of a First TKIs Discontinuation Attempt in Order to Prepare a New Stop
Single-center study, prospective, phase II trial.
The study objectives are :
- To assess safety and pharmacokinetics of the combination of PIO and TKI in CML subjects
who experience a loss of MMR following a first TKI discontinuation.
- To assess survival without loss of MMR over a 12 months period following a second TKI
discontinuation in subjects who achieve or maintain < MR4.5 with the combination PIO and
TKI administered for at least 6 months.
n/a
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