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Clinical Trial Summary

Genicular nerve neurolysis (GN) constitutes a relatively novel technique, whereby different chemical compounds (i.e. alcohol, phenol) are injected in close proximity to the genicular nerves of the knee joint, with the intention to exert a neurolytic effect by denaturing proteins resulting in Wallerian degeneration distal to the lesion. Based on the preliminary evidence and considering the potential benefits of the technique, we hypothesized that ultrasound-guided genicular chemical neurolysis with phenol is superior in terms of pain relief at 3 months, when compared to intra-articular steroid (IAS) injection.


Clinical Trial Description

This study will allow us to determine if ultrasound-guided phenol genicular neurolys is superior to intra-articular steroid injection in terms of analgesia and functional outcomes, providing a more effective and long-lasting alternative for patients with chronic knee pain secondary to osteoarthritis ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06000709
Study type Interventional
Source University of Manitoba
Contact Javier Webar, MD
Phone 2047873018
Email javier.webar@umanitoba.ca
Status Not yet recruiting
Phase Phase 4
Start date October 20, 2023
Completion date July 31, 2024

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