Long Term Follow up of Chronic HCV Patients Receiving DAAS

Status Recruiting

Clinical Trial Summary

Follow up of Chronic hepatitis C Patients with moderate to severe fibrosis and cirrhosis treated with Direct Acting Antivirals after Sustained Virological Response for 4-5 years to detect changes in hepatic fibrosis and liver functions.

Clinical Trial Description

Treatment of chronic hepatitis C is evolving rapidly. Three classes of direct-acting antiviral agents, including inhibitors of the HCV NS3/4A protease, NS5B polymerase, and NS5A have been approved for the treatment of patients with chronic hepatitis C, both in combination with pegylated Interferon (Peg-IFN) / ribavirin (RBV) and, recently, in interferon-free combination. The objective of chronic hepatitis C treatment is to achieve SVR which is defined as the absence of viral replication at 12 or 24 weeks after treatment completion. SVR reduces morbidity and mortality and is equivalent in most cases to cure the HCV infection. Studies have demonstrated that SVR is associated with histological improvement, assessed by liver biopsy, and with the prevention of complications, such as the development of liver cirrhosis and HCC. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05170490
Study type	Observational
Source	Sohag University
Contact	Amira Maher, MD
Phone	00201006789652
Email	amiramaher@med.sohag.edu.eg
Status	Recruiting
Phase
Start date	June 1, 2018
Completion date	March 1, 2023

View Details

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