Chronic Hepatitis C Clinical Trial
Official title:
Regression of Liver Fibrosis Assessed by Transient Elastography After Daclatasvir and Asunaprevir Combined Treatment in Advanced Fibrotic/Cirrhotic Patients With Chronic Hepatitis C Genotype 1b Infection
A study on regression of liver fibrosis assessed by transient elastography after Daclatasvir and Asunaprevir combined treatment in advanced fibrotic/cirrhotic patients with chronic hepatitis C genotype 1b Infection
The measurement of liver stiffness by transient elastography (TE) has been shown to
correlate with the hepatic fibrosis stage and to have considerable accuracy for the
diagnosis of cirrhosis in patients with chronic hepatitis C. Previous studied reported that
liver stiffness is significantly reduced in SVR patients with pegylated interferon (IFN) and
ribavirin treatment. Once a patient achieve sustained virological response (SVR), and
resultingly lower liver stiffness score than baseline value, it is believed that he will
have a better long-term outcome due to the improvement of liver fibrosis.
Daclatasvir(DCV) and Asunaprevir(ASV) combined treatment showed a greater SVR rate in CHC
compared to IFN based therapy. The investigators hypothesize that DCV and ASV combined
treatment may achieve the improvement of liver stiffness measured by TE and a more favorable
clinical outcomes in patients with advanced liver fibrosis. The investigators will also
compare the change of fibrosis stage assessed by TE between this study subjects and those
treated with other DAA agents during same observational period.
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