Chronic Hepatitis C Clinical Trial
Official title:
Association of Vitamin D Binding Protein Polymorphisms With Response to Therapy in Chronic Hepatitis C Egyptian Patients
Introduction: Vitamin D binding protein (VDBP) is a potential modulator of immune response
and is associated with clinical progression of many diseases. Our aim is to assess influence
of baseline 25-hydroxyvitamin D levels and VDBP single nucleotide polymorphisms (SNPs),
rs4588 (C>A) and rs7041 (G>T), on baseline clinical parameters and response to interferon
based therapy in chronic Hepatitis C patients in Egypt.
Methodology: Genotyping will be performed by RFLP (Restriction Fragment Length Polymorphism)
in treatment naïve Hepatitis C patients and healthy controls. Vitamin D levels will be
assessed by ELISA. HCV RNA quantification will be performed by PCR to assess therapy
outcome.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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