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SR-BI and Antiviral Treatment Response in HCV

Chronic Hepatitis C Clinical Trial

Official title:
Influence of Scavenger Receptor Class B Type I (SR-BI) Gene Polymorphisms on Antiviral Treatment Response, and Metabolism in Chronic Hepatitis C Patients

Clinical Trial Summary

The scavenger receptor type B class I (SR-BI) is a receptor for high-density lipoproteins (HDL) and one of entry factors for hepatitis C virus (HCV). The investigators aimed to examine the association of single nucleotide polymorphisms (SNPs) of the SCARB1 gene, which encodes SR-BI, with virologic responses to pegylated interferon-based treatment in Asian chronic hepatitis C (CHC) patients.

Clinical Trial Description

1. Purpose of study: To examine the impacts of single nucleotide polymorphisms (SNPs) relevant to SR-BI on CHC patients.

2. Study Design To enroll 400 CHC patients during a 3-year period

3. Specify objectives of study when collecting extra specimen from participants Collect blood samples for genomic DNA to examine the SR-BI gene polymorphisms.

4. Expected Endpoints of Treatment Sustained virologic response (SVR) means undetectable serum HCV RNA levels 24 weeks after completion of antiviral therapy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02714712
Study type Observational
Source Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Contact
Status Completed
Phase N/A
Start date August 2015
Completion date August 2016
View Details
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