Choroideremia Clinical Trial
Official title:
An Open-Label Safety Study of Retinal Gene Therapy for Choroideremia With Bilateral, Sequential Administration of Adeno-Associated Viral Vector (AAV2) Encoding Rab Escort Protein 1 (REP1)
The objective of the study is to evaluate the safety of bilateral, sequential sub-retinal administration of a single dose of BIIB111 in adult male participants with Choroideremia (CHM).
This study was previously posted by NightstaRx Ltd. In October 2020, sponsorship of the trial was transferred to Biogen. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02553135 -
Choroideremia Gene Therapy Clinical Trial
|
Phase 2 | |
| Completed |
NCT01461213 -
Gene Therapy for Blindness Caused by Choroideremia
|
Phase 1/Phase 2 | |
| Recruiting |
NCT05258032 -
Structural and Functional Characterization of Rare Ocular Diseases
|
||
| Recruiting |
NCT05282953 -
A Phase I/II Dose-escalating Study of the Safety, Tolerability and Efficacy of KIO-301 Administered Intravitreally to Patients With Retinitis Pigmentosa and Choroideremia (ABACUS)
|
Phase 1/Phase 2 | |
| Withdrawn |
NCT05045703 -
The Dark-Adapted Retinal Function Response in Choroideremia (DARC) Study
|
N/A | |
| Recruiting |
NCT01866371 -
High Resolution Retinal Imaging
|
||
| Completed |
NCT01603576 -
Pilot Study of a Suprachoroidal Retinal Prosthesis
|
N/A | |
| Enrolling by invitation |
NCT03584165 -
Long-term Safety and Efficacy Follow-up of BIIB111 for the Treatment of Choroideremia and BIIB112 for the Treatment of X-Linked Retinitis Pigmentosa
|
Phase 3 | |
| Completed |
NCT03359551 -
Natural History of the Progression of Choroideremia Study
|
||
| Recruiting |
NCT02435940 -
Inherited Retinal Degenerative Disease Registry
|
||
| Active, not recruiting |
NCT04483440 -
Dose Escalation Study of Intravitreal 4D-110 in Patients With Choroideremia
|
Phase 1 | |
| Completed |
NCT02670980 -
Compensation for Blindness With the Intelligent Retinal Implant System (IRIS V2) in Patients With Retinal Dystrophy
|
N/A | |
| Completed |
NCT02671539 -
THOR - Tübingen Choroideremia Gene Therapy Trial
|
Phase 2 | |
| Completed |
NCT02341807 -
Safety and Dose-escalation Study of AAV2-hCHM in Participants With CHM (Choroideremia) Gene Mutations
|
Phase 1/Phase 2 | |
| Completed |
NCT03406416 -
Study of a Suprachoroidal Retinal Prosthesis
|
N/A | |
| Enrolling by invitation |
NCT05158049 -
Longitudinal Study of a Bionic Eye
|
||
| Terminated |
NCT02994368 -
"Natural History" Study of Choroideremia
|
||
| Terminated |
NCT01654562 -
The Short-term Effects of Simvastatin on the Vision of Males Affected by Choroideremia
|
Phase 1/Phase 2 | |
| Active, not recruiting |
NCT00427180 -
IRIS PILOT - Extended Pilot Study With a Retinal Implant System
|
N/A | |
| Completed |
NCT04750785 -
A Study to Assess Choroideremia (CHM) Health Outcomes
|