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Clinical Trial Summary

The purpose of this research is to create a collection of bile, bile duct brushings and medical information from people with Primary Sclerosing Cholangitis (PSC) and controls to learn more about changes that occur in the liver.


Clinical Trial Description

The study will ask participants to provide bile and/or bile duct cytology brushings at time of endoscopic retrograde cholangiopancreatography (ERCP) or cholecystectomy (gallbladder removal). The bile and brushings will be used to generate and perpetuate bile-derived organoids using an established matrigel-based protocol. These organoids will then be used in downstream experiments to better understand disease-specific alterations to biological pathways informative of disease pathogenesis ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04753996
Study type Observational
Source Mayo Clinic
Contact Erik Schlicht, CCRP
Phone (507) 284-4212
Email schlicht.erik@mayo.edu
Status Recruiting
Phase
Start date March 8, 2021
Completion date January 2025

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