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Chlamydia Infections clinical trials

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NCT ID: NCT00005547 Completed - Clinical trials for Cardiovascular Diseases

Infection and Cardiovascular Disease

Start date: April 1999
Phase: N/A
Study type: Observational

To investigate the role of chronic infection as a risk factor for vascular disease in a study of Native Americans. The primary focus is on the two most common agents Chlamydia pneumoniae and cytomegalovirus with a secondary emphasis on Helicobacter pylori.

NCT ID: NCT00005496 Completed - Clinical trials for Cardiovascular Diseases

Inflammation, Infection, and Future Cardiovascular Risk

Start date: September 1998
Phase: N/A
Study type: Observational

To examine markers of underlying chronic inflammation and infection as potential risk factors for future myocardial infarction (MI), stroke (CVA), and venous thromboembolism (VTE) in plasma samples collected at baseline from healthy participants in the Physicians' Health Study (PHS).

NCT ID: NCT00001890 Completed - Atherosclerosis Clinical Trials

Effects of Hormone Therapy on the Immune Systems of Postmenopausal Women With Chronic Infections

Start date: May 1999
Phase: Phase 2
Study type: Interventional

Hardening of the arteries (atherosclerosis) and heart disease are much more common in men than in women. However, as women grow older, especially after menopause the incidence of atherosclerosis and heart disease increases. These findings suggest that estrogen may be protective and help in preventing heart disease. Studies of large groups of post-menopausal women suggest that hormone replacement therapy (therapy that includes estrogen) reduces the risk of heart disease. Estrogen causes favorable changes in particles that carry cholesterol in the blood stream and improves function of blood vessels. Estrogen may also stimulate the immune system's ability to fight off infections that may lead to or contribute to atherosclerosis. Researchers believe two specific infectious agents (Chlamydia pneumoniae and human cytomegalovirus) may cause damage to the lining of blood vessels resulting in inflammation and the development of atherosclerosis. The purpose of this study is to determine if estrogen treatment can change how the immune system responds to chronic infections, by Chlamydia pneumoniae and human cytomegalovirus, in postmenopausal women.

NCT ID: NCT00000120 Completed - Clinical trials for Chlamydia Infections

Clinical Trial of Eye Prophylaxis in the Newborn

Start date: January 1985
Phase: Phase 3
Study type: Interventional

To compare the effectiveness of silver nitrate drops, erythromycin ointment, or no medication in preventing neonatal conjunctivitis caused by Chlamydia trachomatis and other eye infections. To compare side effects of the two prophylactic agents.