Comparison of Ultrasound-guided Quadratus Lumborum Block and Iliohypogastric/Ilioinguinal Nerve Block for Postoperative Pain Management in Patients Undergoing Cesarean Section

Cesarean Section Clinical Trial

Official title:

Comparison of Ultrasound-guided Quadratus Lumborum Block and Iliohypogastric/Ilioinguinal Nerve Block for Postoperative Pain Management in Patients Undergoing Cesarean Section: a Randomized Double-blind Clinical Trial Study

Clinical Trial Details — Status: Enrolling by invitation

Administrative data

• NCT number: NCT04822870
• Other study ID #: 2021-Z-01
• Status: Enrolling by invitation
• Phase: N/A
• Start date: March 31, 2021
• Est. completion date: May 2021

Study information

• Verified date: April 2021
• Source: Peking University People's Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to compare the analgesic effect of ultrasound-guided quadratus lumborum block and iliohypogastric/ilioinguinal nerve block for postoperative pain management in patients undergoing cesarean section.

Recruitment information / eligibility

• Status: Enrolling by invitation
• Enrollment: 87
• Est. completion date: May 2021
• Est. primary completion date: May 2021
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• singleton pregnancy
• gestation of at least 37 weeks
• American Society of Anesthesiologists (ASA) physical status I or II
• finish Pfannenstiel section under combined spinal and epidural anesthesia

Exclusion Criteria:

• pruritus existed before the surgery
• allergic to lidocaine, ropivacaine or dexamethasone

Related Conditions & MeSH terms

• Cesarean Section
• Iliohypogastric/Ilioinguinal Nerve Block
• Pain, Postoperative
• Quadratus Lumborum Block

Intervention

Procedure:
• quadratus lumborum block
Quadratus lumborum block is an effective nerve block method in post-cesarean section analgesia. It is a relatively new technique that may provide analgesic effect in somatic pain and visceral pain, but has not been verified yet.
• iliohypogastric/ilioinguinal nerve block
Iliohypogastric/ilioinguinal nerve block is a widely used nerve block technique. It can provide somatic analgesia effect in post-cesarean section.
• epidural analgesia
Epidural analgesia is a traditional analgesia method. Epidural morphine can provide effective analgesia but may cause plenty adverse effect.

Locations

Country	Name	City	State
China	Peking University People's Hospital	Beijing	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Peking University People's Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	morphine consumption	Every parturient use a patient-controlled intravenous analgesia pump as supplement for the interventions. The analgesia pump contains morphine and can record morphine consumption. Postoperative use of morphine can reflect analgesic effect.	24 hours postoperatively
Secondary	morphine consumption	Every parturient use a patient-controlled intravenous analgesia pump as supplement for the interventions. The analgesia pump contains morphine and can record morphine consumption. Postoperative use of morphine can reflect analgesic effect.	6 hours postoperatively
Secondary	morphine consumption	Every parturient use a patient-controlled intravenous analgesia pump as supplement for the interventions. The analgesia pump contains morphine and can record morphine consumption. Postoperative use of morphine can reflect analgesic effect.	12 hours postoperatively
Secondary	morphine consumption	Every parturient use a patient-controlled intravenous analgesia pump as supplement for the interventions. The analgesia pump contains morphine and can record morphine consumption. Postoperative use of morphine can reflect analgesic effect.	48 hours postoperatively
Secondary	pain score	Use visual analogue scale (VAS) 0-10 to evaluate pain intensity and reflect analgesic effect. 0 refers to completely no pain, 10 refers to the most severe pain she has experienced.	6 hours postoperatively
Secondary	pain score	Use visual analogue scale (VAS) 0-10 to evaluate pain intensity and reflect analgesic effect. 0 refers to completely no pain, 10 refers to the most severe pain she has experienced.	12 hours postoperatively
Secondary	pain score	Use visual analogue scale (VAS) 0-10 to evaluate pain intensity and reflect analgesic effect. 0 refers to completely no pain, 10 refers to the most severe pain she has experienced.	24 hours postoperatively
Secondary	pain score	Use visual analogue scale (VAS) 0-10 to evaluate pain intensity and reflect analgesic effect. 0 refers to completely no pain, 10 refers to the most severe pain she has experienced.	48 hours postoperatively
Secondary	effective analgesia time	Time period between finish the intervention and the first time parturient use the patient-controlled intravenous analgesia pump for analgesia supplement.	48 hours postoperatively
Secondary	adverse effect	Nausea and vomiting, pruritus, oversedation, respiratory depression and urinary retention are considered adverse effects. The incidence and severity are recorded, 1 score refers to mild, 2 scores refers to moderate, 3 scores refers to severe and treatment needed.	6 hours postoperatively
Secondary	adverse effect	Nausea and vomiting, pruritus, oversedation, respiratory depression and urinary retention are considered adverse effects. The incidence and severity are recorded, 1 score refers to mild, 2 scores refers to moderate, 3 scores refers to severe and treatment needed.	12 hours postoperatively
Secondary	adverse effect	Nausea and vomiting, pruritus, oversedation, respiratory depression and urinary retention are considered adverse effects. The incidence and severity are recorded, 1 score refers to mild, 2 scores refers to moderate, 3 scores refers to severe and treatment needed.	24 hours postoperatively
Secondary	adverse effect	Nausea and vomiting, pruritus, oversedation, respiratory depression and urinary retention are considered adverse effects. The incidence and severity are recorded, 1 score refers to mild, 2 scores refers to moderate, 3 scores refers to severe and treatment needed.	48 hours postoperatively
Secondary	satisfaction score	Ask the patient to evaluate satisfaction score using 0-10. 0 refers totally dissatisfied, 10 refers to the most satisfied	48 hours postoperatively
Secondary	hospital stay	The hospitalize length	at discharge assessed up to 10 days
Secondary	hospitalize cost	Total cost in this hospitalization	at discharge assessed up to 10 days