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NCT00422474 Clinical Trial

Prognostic Significance of the Baroreflex Sensitivity Changes After Acute Ischemic Stroke

Cerebrovascular Accident Clinical Trial

Official title:
Noninvasive Study of the Time Course of Baroreflex Sensitivity 6-Month After Acute Ischemic Stroke and the Relation of Its Changes With Post Stroke Prognosis

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT00422474
Other study ID # FEMH-95-C-012
Secondary ID
Status Recruiting
Phase N/A
First received January 14, 2007
Last updated July 8, 2008
Start date January 2007

Study information
Verified date July 2008
Source Far Eastern Memorial Hospital
Contact Siupak Lee, M.D.
Email siupakmd@ms1.hinet.net
Is FDA regulated No
Health authority Taiwan: Department of Health
Study type Observational

Clinical Trial Summary

After acute stroke, baroreflex sensitivity (BRS) is impaired. This impaired acute stage BRS has been reported to be predictive of worsen outcome years after stroke in general. However, it is not very clear if the impaired acute stroke BRS would actually persist months after the acute stage. It is also not clear that such change, if any, would correlate with the functional outcome or prognosis after stroke.

The trial is to investigate the longitudinal time course of BRS after ischemic stroke up to the 6th month post stroke and to see if there is any correlation of the changes in BRS with the functional outcome parameters using NIHSS and mRS scores throughout this period.

Recruitment information / eligibility
Status Recruiting
Enrollment 100
Est. completion date
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 50 Years to 80 Years
Eligibility Inclusion Criteria:

- Baroreflex sensitivity can be done within 72 hours of onset of acute ischemic stroke

- 50-80 years old

- Must have either brain CT or brain MRI done

Exclusion Criteria:

- NIHSS score > 10

- Patient could not cooperate

- Unstable vital sign

- Atrial fibrillation

- Transient ischemic attack patient

- Diabetic patient

- Impaired renal function (Cr > 2.26 mg/dl)

- Unstable angina, acute myocardiac infarction, cardiomyopathy patients

- Patient who has known autonomic dysfunction

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Taiwan Far Eastern Memorial Hospital Panchiao City Taipei County

Sponsors (1)
Lead Sponsor Collaborator
Far Eastern Memorial Hospital

Country where clinical trial is conducted

Taiwan, 

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