Cerebro-vascular Disease Clinical Trial
Official title:
4D FLOW: Feasibility Study of a Sequence 4D of Flow Applied to the Cervico-encephalic Vascular Pathologies
The dynamic angio-MR sequences with injection of contrast (CE ARM) allow the study of the
vascular anatomy. These sequences, widely used in clinical routine have shown their utility,
in particular in the detection of the cerebrovascular diseases. The 4D flow MR sequences
allow to quantify arterial parameters such as the speed of the circulating flow. By allowing
an anatomical analysis and a functional analysis of quantitative parameters, 4D flow MR
sequences could replace 1/ the currently used dynamic MRA sequences that are less precise in
term of spatial and temporal resolution; 2/ the invasive exploration by DSA for the detection
of vascular lesion and complete the exploration of the cervico-encephalic vascular
pathologies by providing hemodynamical measures not yet accessible in clinical settings.
In this context, the aim of the study is to evaluate the feasibility and the clinical
usefulness of this 4D Flow technique to image brain vascular disorders including steno
occlusive disorders. The evaluation will include several steps: 1/ optimization of
acquisition parameters for the cranio-cervical arteries; 2/ comparison of two strategies for
the post-processing 3/ feasibility for imaging of brain vascular disorders.
The dynamic angio-MR sequences with injection of contrast (CE ARM) allow the study of the
vascular anatomy. These sequences, widely used in clinical routine have shown their utility,
in particular in the detection of the cerebrovascular diseases. The 4D flow MR sequences
allow to quantify arterial parameters such as the speed of the circulating flow. By allowing
an anatomical analysis and a functional analysis of quantitative parameters, 4D flow MR
sequences could replace 1/ the currently used dynamic MRA sequences that are less precise in
term of spatial and temporal resolution; 2/ the invasive exploration by DSA for the detection
of vascular lesion and complete the exploration of the cervico-encephalic vascular
pathologies (arterio-venous deformations, cervical or intra-cranial stenoses, intra-cranial
aneurysms) by providing hemodynamical measures not yet accessible in clinical settings.
In this context, the aim of the study is to evaluate the feasibility and the clinical
usefulness of this 4D Flow technique to image brain vascular disorders including steno
occlusive disorders. The evaluation will include several steps: 1/ optimization of
acquisition parameters for the cranio-cervical arteries; 2/ comparison of two strategies for
the post-processing 3/ feasibility for imaging of brain vascular disorders.
STUDY HYPOTHESIS & AIMS The investilgators hypothesized that, once optimized for brain and
cervical acquisition, 4D flow MRA will provides quantitative information not available with
other routinely available dynamic MR sequences. The main goal of this study is to demonstrate
the feasibility of a non-invasive evaluation of hemodynamics (quantitative speed measurements
and flow tracking) in neuro applications using the 4D Flow prototype. The secondary goal is
to compare parameters derived from 4D Flow prototype using two post-processing pipelines.
4D Flow images will be compared to other available hemodynamic information obtained as part
of the routine clinical care in order to assess whether additional clinically relevant
information can be extracted.
The study of the arterio-venous deformations and the study of the supraaortic trunks require
the realization of MRI sequences with injection of Gd during a clinical protocol of routine.
The sequence added at the end of protocol does not modify the injection with clinical
purpose.
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