Clinical Trials Logo

Cerebral Vasospasm clinical trials

View clinical trials related to Cerebral Vasospasm.

Filter by:

NCT ID: NCT06303349 Recruiting - Cerebral Vasospasm Clinical Trials

Predictive Model for the Occurrence of Cerebral Vasospasm Complicating Subarachnoid Haemorrhage by Combined Analysis of the Kinetics of a Panel of Biomarkers.

CVSBIODIAG
Start date: May 7, 2024
Phase: N/A
Study type: Interventional

The objective is to create a dynamic clinical prediction model that includes routinely measured care and biological biomarkers to predict cerebral vasospasm within 14 days of bleeding in patients treated in the neurosurgical intensive care unit for subarachnoid hemorrhage. Patients admitted to intensive care will be followed for up to 14 days (D14 time horizon of interest), or until discharge from intensive care if earlier. Blood samples will be taken from D1 to D10 to isolate the blood biomarkers of interest for each patient. The measurement of biomarkers and cerebral vasospasm will be blinded to each other.

NCT ID: NCT05230134 Enrolling by invitation - Anesthesia, Local Clinical Trials

Cervical Sympathetic Block in Patients With Cerebral Vasospasm

Start date: July 27, 2023
Phase: N/A
Study type: Interventional

The purposes of this study are twofold: 1) to assess the effect of a cervical sympathetic block on cerebral blood flow in patients suffering from cerebral vasospasm, after aneurysmal subarachnoid hemorrhage; 2) to evaluate the effect of the sympathetic block on the recovery of the neurological function.

NCT ID: NCT05150002 Recruiting - Clinical trials for Subarachnoid Hemorrhage

Cervical Spinal Cord Stimulation in Patients With Cerebral Vasospasm After Subarachnoid Haemorrhage: VasoStim Study

Start date: June 30, 2023
Phase: N/A
Study type: Interventional

Cerebral vasospasm is characterized by a vasoconstriction of cerebral arteries causing a reduction of cerebral blood flow (CBF) and leading to ischemia and infarction of the brain parenchyma. Cerebral vasospasm is a serious complication of aneurysmal subarachnoid hemorrhage (SAH) with high morbidity and overall mortality of 40-50%. Although the exact mechanisms of spinal cord stimulation (SCS) on the innervation of cerebral vessels are still unclear, several hypotheses have been formulated and studies in animals and human performed with very promising results. This is a proof of concept study to better understand the effect and mechanisms of cervical spinal cord stimulation on cerebral vasospasm after aneurysmal SAH in human.

NCT ID: NCT04691271 Recruiting - Clinical trials for Aneurysmal Subarachnoid Hemorrhage

Stellate Ganglion Block and Cerebral Vasospasm

BLOCK-CVS
Start date: July 1, 2021
Phase: N/A
Study type: Interventional

At present, cerebral vasospasm (cVS) is the main cause of delayed cerebral infarction (DCI), which leads to high disability and mortality rate after aneurysmal subarachnoid hemorrhage. As a consequence, the key of reducing DCI is to prevent cVS. But unfortunately, despite years of efforts, the prevention and treatment of cVS is still a major clinical dilemma and various ways of treatment are still being explored. Recent studies have shown that stellate ganglion block (SGB) can dilate cerebral vessels and alleviate the impact of existing cVS. However, there is no study to evaluate the effect of early application of SGB on the improvement and prevention of cVS after aSAH.

NCT ID: NCT04613960 Not yet recruiting - Clinical trials for Subarachnoid Hemorrhage, Aneurysmal

Magnesium Treating Subarachnoid Hemorrhage Vasospasm

MATSH-SHapE
Start date: December 2022
Phase: Phase 2/Phase 3
Study type: Interventional

A randomized clinical trial investigating magnesium sulphate ability to reduce risk of cerebral vasospasm after acute subarachnoid hemorrhage hence improving outcome particularly in haptoglobin 2-2 patients who are highly susceptible for severe complications after subarachnoid hemorrhage.

NCT ID: NCT04512859 Not yet recruiting - Clinical trials for Subarachnoid Hemorrhage, Aneurysmal

Stellate Ganglion Block in Preventing Cerebral Vasospasm Secondary to Subarachnoid Hemorrhage

Start date: September 1, 2020
Phase: N/A
Study type: Interventional

To investigate whether the stellate ganglion block is helpful in relieving cerebral vasospasm during aneurysmal coil embolism surgery. The effect was assessed by Transcranial Doppler (TCD).

NCT ID: NCT04208477 Completed - Clinical trials for Traumatic Brain Injury

"The Effect of Stellate Ganglion Block in Severe Brain Injury"

Start date: November 1, 2021
Phase: N/A
Study type: Interventional

Blood flow through the brain is reduced after brain damage. Secondary brain ischemia caused by hypoxia and hypotension, further increase the susceptibility of the ischemically compromised brain to secondary impairment during this period. In order to determine whether and to what extent blockage of the stellate ganglion (BSG) affects the blood flow to the injured brain, the investigators will measure the variables of brain blood flow before and after BSG using computed tomography angiography (CTA), trans-cranial Doppler ultrasound (TCD), intracranial pressure (ICP) and perfusion computed tomography (PCT) of the brain. At the same time, the investigators would like to evaluate whether and to what extent BSG affects the aseptic inflammatory brain injury response and the biochemical indicators of brain damage in patients with moderate and severe brain injury.

NCT ID: NCT03611790 Completed - Cerebral Vasospasm Clinical Trials

Vesalio NeVa VS for Symptomatic Cerebral Vasospasm Following aSAH (The VITAL Study)

Start date: December 19, 2018
Phase: N/A
Study type: Interventional

The objective of the study is to assess the safety and probable benefit of the Neva VS device in patients presenting with symptomatic cerebral vasospasm despite maximal medical management following aSAH.

NCT ID: NCT03517670 Completed - Clinical trials for Subarachnoid Hemorrhage

Safety of Intravenous Milrinone for the Treatment of Subarachnoid Hemorrhage-induced Vasospasm

MilriSpasm
Start date: August 31, 2020
Phase:
Study type: Observational [Patient Registry]

The aim of this study is to evaluate the tolerance of intravenous milrinone combined to the current standard treatment for cerebral vasospasm following subarachnoid hemorrhage. Assessment of IV milrinone safety in this setting is mandatory before the conduction of a large study assessing its effectiveness.

NCT ID: NCT03214705 Completed - Clinical trials for Subarachnoid Hemorrhage

Role of CT Perfusion in Predicting Poor Outcome After Subarachnoid Hemorrhage

Start date: March 1, 2016
Phase:
Study type: Observational [Patient Registry]

Prospective evaluation of patients with subarachnoid hemorrhage (SAH) will be done by computed tomography angiography (CTA) and perfusion imaging (CTP) for any correlation between degree of vasospasm and perfusion deficit as well as evaluating the ability of CTP to predict delayed cerebral ischemia.