Transcranial Doppler Ultrasound in Critically Ill Patients With Cardiovascular Comorbidities

Cerebral Vascular Disorder Clinical Trial

— CRITIDOP  

Official title:

Transcranial Doppler Ultrasound and Arterial Diseases: Description of Ultrasound Patterns in a Critically Ill Population Without Neurological Disorders.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03043092
• Other study ID #: IRB 14/05-02
• Status: Completed
• Start date: June 14, 2016
• Est. completion date: September 19, 2018

Study information

• Verified date: January 2019
• Source: Centre Hospitalier Universitaire de Nimes
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Transcranial Doppler ultrasound is bedside tool use to assess cerebral blood perfusion in critically ill patients. We sought to conduct a prospective, single centre study aiming to determine whether chronic vascular diseases may be a confounder in transcranial Doppler ultrasound assessment in critically ill patients.

Description:

Intracranial hypertension is associated with altered transcranial doppler parameters measured in the middle cerebral artery such as decreasing diastolic velocity and increasing pulsatility index with higher intracranial pressure (ICP). Chronic vascular diseases in modifying arterial resistance may interfere with transcranial Doppler ultrasound assessment mimicking intracranial hypertension profile.

The aim of this prospective, single centre study enrolling critically ill patients without any acute neurological disease is to to determine the pattern of transcranial Doppler ultrasound variables amongst patients with and without chronic vascular diseases.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 91
• Est. completion date: September 19, 2018
• Est. primary completion date: September 19, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• patient intubated, ventilated, adaptated on ventilator

• affiliated to healthcare insurance

• patient available for 24h follow up

• patient >18 years

Exclusion Criteria:

• admitted in ICU for cerebral aggression (<3 month): stroke, trauma brain injury, meningitis

• carotid surgery <1 month

• patient refuse to consent

• legal guardianship

• pregnancy

• mean blood pressure <65mmHg or >100mmHg

• non echogenic patient

• hypoglycemia <0.6g/l

• pH<7.30

• T°<35°C

• Patient already included in this study

Related Conditions & MeSH terms

• Cerebral Vascular Disorder
• Cerebrovascular Disorders
• Critical Illness
• Vascular Diseases

Locations

Country	Name	City	State
France	Nimes University hospital	Nimes

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire de Nimes

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Transcranial Doppler ultrasound assessment of pulsatility index in middle cerebral arteries		first twenty four hours of ICU admission
Primary	Transcranial Doppler ultrasound assessment of diastolic velocity in middle cerebral arteries		first twenty four hours of ICU admission
Primary	Transcranial Doppler ultrasound assessment of mean velocity in middle cerebral arteries		first twenty four hours of ICU admission
Secondary	Transcranial Doppler ultrasound assessment of systolic velocity in middle cerebral arteries		first twenty four hours of ICU admission
Secondary	Transcranial Doppler ultrasound assessment of resistive index in middle cerebral arteries		first twenty four hours of ICU admission
Secondary	Carotid Doppler ultrasound assessment of systolic, mean and diastolic velocity		ten days of ICU admission
Secondary	Pulse wave velocity		ten days of ICU admission